piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells
piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells
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piR-823是一种新型非编码小RNA，在人胃癌细胞中表现出体外和体内肿瘤抑制活性
DOI：
10.1016/j.canlet.2011.10.004
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发表时间：
2012-02-01
期刊：
影响因子：
9.7
通讯作者：
Guo, Junming
中科院分区：
文献类型：
--
作者：
Cheng, Jia;Deng, Hongxia;Guo, Junming
Piwi相互作用RNAs(PiRNAs)是一种新的非编码小RNA，与染色质组织、信使RNA稳定性和基因组结构有关。然而，piRNA在肿瘤发生中的作用还不是很清楚。应用实时荧光定量逆转录聚合酶链式反应技术发现，Pir-823在胃癌组织中的表达水平显著低于非癌组织。胃癌细胞中Pir-823水平升高后，细胞生长受到抑制。裸鼠移植瘤模型的实验结果证实了其抑瘤作用。所有证据表明，Pir-823在胃癌的隐匿性中起着重要作用。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the expression level of piR-823 in gastric cancer tissues was significant lower than that in non-cancerous tissues. After increase the level of piR-823 in gastric cancer cells, cell growth was inhibited. The results of xenograft nude mice model confirmed its tumor suppressive properties. All of the evidences indicated that piR-823 play a crucial role in the occult of gastric cancer. (C) 2011 Elsevier Ireland Ltd. All rights reserved.