Application of the asthma phenotype algorithm from the Severe Asthma Research Program to an urban population.
Application of the asthma phenotype algorithm from the Severe Asthma Research Program to an urban population.
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DOI：
10.1371/journal.pone.0044540
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Reibman J
中科院分区：
文献类型：
--
作者：
Patrawalla P;Kazeros A;Rogers L;Shao Y;Liu M;Fernandez-Beros ME;Shang S;Reibman J
由于疾病的复杂性和异质性，哮喘表型的鉴定和表征具有挑战性。严重哮喘研究计划（SARP）使用无监督聚类分析来定义5个表型不同的哮喘聚类，他们在简化算法中使用3个变量复制。我们评估了这种简化的SARP算法是否可以用于一个单独的和多样化的城市哮喘人群，以重建这5个表型集群。SARP简化算法应用于纽约大学/贝尔维尤哮喘登记处（NYUBAR）招募的成人哮喘患者，将患者分为5组。对临床表型进行总结和比较。NYUBAR（n = 471）的哮喘受试者主要是女性（70%）和西班牙裔（57%），这与SARP人群的人口统计学差异。 通过简化SARP算法生成的5个组的临床表型在各组间不同，分布与SARP人群中描述的相似。第1组和第2组（分别为6%和63%）主要患有儿童期发作的特应性哮喘。第4组和第5组（20%）年龄较大，哮喘持续时间最长，症状增加和加重。第4组受试者的特应性最强，外周嗜酸性粒细胞最高。第3组（10%）有最少的特应性，但包括老年肥胖妇女与成人发作的哮喘，并增加恶化。应用简化的SARP算法的NYUBAR产生的组，是表型不同的和有用的表征疾病的异质性。NYUBAR组间的差异支持表型变异，并支持在未来的前瞻性研究中使用简化SARP算法对哮喘表型进行分类，以研究这些不同组之间的治疗和结局差异。Clinicaltrials.gov NCT00212537
Identification and characterization of asthma phenotypes are challenging due to disease complexity and heterogeneity. The Severe Asthma Research Program (SARP) used unsupervised cluster analysis to define 5 phenotypically distinct asthma clusters that they replicated using 3 variables in a simplified algorithm. We evaluated whether this simplified SARP algorithm could be used in a separate and diverse urban asthma population to recreate these 5 phenotypic clusters. The SARP simplified algorithm was applied to adults with asthma recruited to the New York University/Bellevue Asthma Registry (NYUBAR) to classify patients into five groups. The clinical phenotypes were summarized and compared. Asthma subjects in NYUBAR (n = 471) were predominantly women (70%) and Hispanic (57%), which were demographically different from the SARP population. The clinical phenotypes of the five groups generated by the simplified SARP algorithm were distinct across groups and distributed similarly to those described for the SARP population. Groups 1 and 2 (6 and 63%, respectively) had predominantly childhood onset atopic asthma. Groups 4 and 5 (20%) were older, with the longest duration of asthma, increased symptoms and exacerbations. Group 4 subjects were the most atopic and had the highest peripheral eosinophils. Group 3 (10%) had the least atopy, but included older obese women with adult-onset asthma, and increased exacerbations. Application of the simplified SARP algorithm to the NYUBAR yielded groups that were phenotypically distinct and useful to characterize disease heterogeneity. Differences across NYUBAR groups support phenotypic variation and support the use of the simplified SARP algorithm for classification of asthma phenotypes in future prospective studies to investigate treatment and outcome differences between these distinct groups. Clinicaltrials.gov NCT00212537
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DOI：
10.1016/j.jaci.2011.03.036
发表时间：
2011-06
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Holguin F;Bleecker ER;Busse WW;Calhoun WJ;Castro M;Erzurum SC;Fitzpatrick AM;Gaston B;Israel E;Jarjour NN;Moore WC;Peters SP;Yonas M;Teague WG;Wenzel SE
通讯作者：
Wenzel SE
影响因子：
14.2
作者：
Wisnivesky, Juan P.;Sampson, Hugh;Halm, Ethan A.
通讯作者：
Halm, Ethan A.
TSLP和哮喘的遗传变异在混合城市人口中。
影响因子：
3.7
作者：
Liu M;Rogers L;Cheng Q;Shao Y;Fernandez-Beros ME;Hirschhorn JN;Lyon HN;Gajdos ZK;Vedantam S;Gregersen P;Seldin MF;Bleck B;Ramasamy A;Hartikainen AL;Jarvelin MR;Kuokkanen M;Laitinen T;Eriksson J;Lehtimäki T;Raitakari OT;Reibman J
通讯作者：
Reibman J
DOI：
10.1164/ajrccm.152.3.7663792
发表时间：
1995-09-01
影响因子：
24.7
作者：
通讯作者：
--
影响因子：
9.6
作者：
Rogers, L;Cassino, C;Reibman, J
通讯作者：
Reibman, J