Cardiac systems biology
Cardiac systems biology
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DOI：
10.1196/annals.1341.025
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Paternostro, G
中科院分区：
文献类型：
--
作者：
McCulloch, AD;Paternostro, G
随着心脏生物学和其他健康和疾病复杂系统的详细分子信息的积累，对新的综合分析和工具的需求正在增长。系统生物学和生物工程寻求使用高通量技术和综合计算分析来构建系统中分子组分之间相互作用的网络，开发其功能集成生物学特性的系统模型，并将这些系统模型纳入结构集成的多尺度模型中，以预测临床表型。这篇综述给出了最近应用这些方法来阐明心脏在衰老和疾病中的机电功能的例子。
As more detailed molecular information accumulates on the biology of the heart and other complex systems in health and disease, the need for new integrative analyses and tools is growing. Systems biology and bioengineering seek to use high-throughput technologies and integrative computational analysis to construct networks of the interactions between molecular components in the system, to develop systems models of their functionally integrated biological properties, and to incorporate these systems models into structurally integrated multi-scale models for predicting clinical phenotypes. This review gives examples of recent applications using these approaches to elucidate the electromechanical function of the heart in aging and disease.