Lycium barbarum polysaccharides as an adjuvant for recombinant vaccine through enhancement of humoral immunity by activating Tfh cells
Lycium barbarum polysaccharides as an adjuvant for recombinant vaccine through enhancement of humoral immunity by activating Tfh cells
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枸杞多糖作为重组疫苗佐剂通过激活Tfh细胞增强体液免疫
DOI：
10.1016/j.vetimm.2013.05.006
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发表时间：
2014-03-15
影响因子：
1.8
通讯作者：
Wang, Ning-ping
中科院分区：
文献类型：
--
作者：
Su, Chun-xia;Duan, Xiang-guo;Wang, Ning-ping
枸杞多糖（LBP）具有多种免疫调节功能，包括活化T细胞和B细胞。滤泡辅助T细胞（Tfh）现在被认为是辅助T细胞的一个亚群，它调节B细胞成熟和功能的多个阶段。在我们目前的研究中，我们发现LBP能够激活CXCR5+PD-1+ Tfh细胞，诱导IL-21分泌。同时，LBP还促进生发中心（germinal centers， GC）的形成和GL-7+B220+GC B细胞的产生。LBP作为佐剂可增加rad5vp1诱导的Tfh细胞的生成。我们的研究结果表明，LBP可能通过作为Tfh细胞生成的佐剂来增强T细胞依赖性的Ab反应。因此，未来的疫苗设计可能会有针对性地诱导强烈的抗原特异性Tfh反应，以增强其保护作用。(C) 2013 Elsevier B.V.版权所有
Lycium barbarum polysaccharides (LBP) have been shown to play a variety of immunemodulatory functions which include activation of T and B cells. Follicular helper T (Tfh) cells are now recognized as a subset of helper T cells which regulate the multiple stages of B cell maturation and function. In our current study, we found that LBP were able to activate CXCR5+PD-1+ Tfh cells and induce IL-21 secretion. At the same time LBP also promoted the formation of germinal centers (GC) and production of GL-7+B220+GC B cells. LBP as an adjuvant could increase generation of rAd5VP1-induced Tfh cells. Our results indicate that LBP might enhance T cell-dependent Ab responses by acting as an adjuvant for the generation of Tfh cells. Future vaccine designs might therefore be targeted to induce strong antigen-specific Tfh responses in order to boost its protective effects. (C) 2013 Elsevier B.V. All rights reserved.