The Inflammatory-Nutritional Index: assessing nutritional status and prognosis in gastrointestinal and lung cancer patients
The Inflammatory-Nutritional Index: assessing nutritional status and prognosis in gastrointestinal and lung cancer patients
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DOI：
10.3305/nh.2014.29.3.7195
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发表时间：
2014-03-01
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影响因子：
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通讯作者：
Gonzalez, Maria Cristina
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文献类型：
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作者：
Alberici Pastore, Carla;Paiva Orlandi, Silvana;Gonzalez, Maria Cristina
目的：评估炎症营养指数（INI）对胃肠癌和肺癌患者的预后能力。方法：纵向研究，包括 2008 年 7 月至 2010 年 5 月期间来自巴西化疗服务的患者。评估 INI（白蛋白/CRP）和营养状况（通过主观整体评估 - SGA）。风险 INI 定义为低于 0.35。平均随访生存期为 1.6 年。使用Stata 11.1（TM）进行统计分析。结果：74名患者参与了该研究，平均年龄63.4岁，其中大多数为男性（58%），患有胃肠道癌症（71%）。 87% 的患者存在营养不良（22% 为严重营养不良）。平均 INI 为 2.67，54% 的患者 INI 水平被视为风险。随访期间有 49 人死亡（66%）。 INI 风险患者的中位生存时间明显短于正常 INI 患者 (p = 0,002)。 INI风险子样本下降50%需要0.78年，而正常INI子样本需要2.78年。 INI 风险和严重营养不良是生存不良的独立预测因素。结论：INI 在该样本中显示出预后能力，并且可能是基于常规血液测试评估癌症患者的有用工具。
Objective: To evaluate the prognostic capacity of the Inflammatory-Nutritional Index (INI) in gastrointestinal and lung cancer patients.Methods: Longitudinal study, including patients from a chemotherapy service in Brazil, between July 2008 and May 2010. INI (Albumin/CRP) and nutritional status (by Subjective Global Assessment - SGA) were evaluated. Risk INI was defined as lower than 0.35. The mean follow-up of survival was 1.6 year. Statistical analyses were performed using Stata 11.1 (TM).Results: 74 patients participated in the study, mean age 63.4, most of them male (58%) and presenting gastrointestinal cancer (71%). Malnutrition was identified in 87% of the patients (22% severely malnourished). The mean INI was 2.67 and 54% of the patients had INI levels considered as risk. During the follow-up there were 49 deaths (66%). The median survival time for INI risk patients was significantly shorter than for normal INI ones (p = 0,002). It took 0.78 year for the INI risk subsample to decline 50%, while it took 2.78 year for the normal INI subsample. INI risk and severe malnutrition were independent predictors for poor survival.Conclusion: The INI showed prognostic capacity in this sample and may be a useful tool, based on routinely available blood tests, to assess cancer patients.