Vascular effects of photodynamic therapy.
Vascular effects of photodynamic therapy.
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DOI：
10.1089/clm.1996.14.323
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发表时间：
1996-10
期刊：
影响因子：
--
通讯作者：
V. Fingar
中科院分区：
文献类型：
--
作者：
V. Fingar
血管损伤和血流停滞是使用许多光敏剂对实体瘤进行光动力疗法（PDT）的结果。微血管停滞和由此产生的缺氧是产生细胞毒性和肿瘤消退的有效手段。光动力治疗后观察到的血流停滞是由微脉管系统内敏感部位的损伤以及对这种损伤产生的生理反应共同造成的。导致血管停滞的机制的广义假设始于光敏组织的光治疗过程中内皮细胞的扰动和损伤。内皮细胞损伤导致血管腔内形成血栓位点，并引发一系列生理反应，包括血小板聚集、血管活性分子释放、白细胞粘附、血管通透性增加和血管收缩。这些损伤的影响结合起来会产生血流停滞。
Vascular damage and blood flow stasis are consequences of photodynamic therapy (PDT) of solid tumors using many photosensitizers. Microvascular stasis and resulting hypoxia are effective means to produce cytotoxicity and tumor regression. The observation of blood flow stasis after photodynamic therapy results from a combination of damage to sensitive sites within the microvasculature and the resulting physiological responses to this damage. A generalized hypothesis for the mechanisms leading to vessel stasis begins with perturbation and damage to endothelial cells during light treatment of photosensitized tissues. Endothelial cell damage leads to the establishment of thrombogenic sites within the vessel lumen and this initiates a physiological cascade of responses including platelet aggregation, the release of vasoactive molecules, leukocyte adhesion, increases in vascular permeability, and vessel constriction. These effects from damage combine to produce blood flow stasis.