DIFFERENTIAL DEVELOPMENT OF PROGENITOR ACTIVITY FOR 3 B-CELL LINEAGES
DIFFERENTIAL DEVELOPMENT OF PROGENITOR ACTIVITY FOR 3 B-CELL LINEAGES
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DOI：
10.1073/pnas.89.8.3320
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发表时间：
1992-04-15
影响因子：
11.1
通讯作者：
HERZENBERG, LA
中科院分区：
文献类型：
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作者：
KANTOR, AB;STALL, AM;HERZENBERG, LA
本文介绍的细胞转移研究区分了三种小鼠B细胞系：常规B细胞，其发育较晚，并从成人骨髓中的祖细胞不断补充; Ly-1 B细胞（B-1a），其发育较早，并通过自我补充维持其数量;和Ly-1 B“姐妹”（B-1 B）细胞，它们具有Ly-1 B细胞的许多特性，包括自我补充和发育的反馈调节，但也可以容易地从成人骨髓中的祖细胞发育。这些谱系的相继出现，它们的祖先在个体发育过程中发挥作用的时间，以及它们的库和功能之间的区别表明，进化创造了一个分层的免疫系统，其中每个连续谱系的免疫反应潜力适应其特定的生态位。
Cell-transfer studies presented here distinguish three murine B cell lineages: conventional B cells, which develop late and are continually replenished from progenitors in adult bone marrow; Ly-1 B cells (B-1a), which develop early and maintain their numbers by self-replenishment; and Ly-1 B "sister" (B-1b) cells, which share many of the properties of Ly-1 B cells, including self-replenishment and feedback regulation of development but can also readily develop from progenitors in adult bone marrow. The sequential emergence of these lineages, the time at which their progenitors function during ontogeny, and the distinctions among their repertoires and functions suggest that evolution has created a layered immune system in which the immune response potential of each successive lineage is adapted to its particular niche.