Executive dysfunction and apathy predict functional impairment in Alzheimer disease
Executive dysfunction and apathy predict functional impairment in Alzheimer disease
复制标题
DOI：
10.1176/appi.ajgp.11.2.214
复制
发表时间：
2003-03-01
影响因子：
7.2
通讯作者：
Cummings, JL
中科院分区：
文献类型：
--
作者：
Boyle, PA;Malloy, PF;Cummings, JL
目的：本研究的目的是检查轻度至中度阿尔茨海默病（AD）患者的执行认知功能障碍和前部介导的行为障碍与功能障碍的相关程度。研究方法：AD患者（N = 45）完成了Mattis痴呆评定量表，患者的护理人员完成了额叶系统行为调查表和改良形式的Lawton和Brody日常生活活动（ADL）问卷。结果如下：多元回归分析显示，执行认知功能障碍和冷漠分数占44%的工具性日常生活活动的方差;执行认知功能障碍单独解释17%的工具性日常生活活动的方差，和冷漠分数解释了额外的27%。执行功能障碍和额叶行为障碍解释了28%的基本ADL（BADL）的方差，并且，在解释执行功能障碍后，冷漠是唯一的症状，可以解释额外的独特的BADL方差。结论：AD患者的认知和行为症状与功能损害有关。
Objective: The purpose of this study was to examine the extent to which executive cognitive dysfunction and frontally-mediated behavioral disturbances are associated with functional impairment in patients with mild-to-moderate Alzheimer disease (AD). Methods: Patients with AD (N = 45) completed the Mattis Dementia Rating Scale, and patients' caregivers completed the Frontal Systems Behavioral Inventory and a modified form of the Lawton and Brody Activities of Daily Living (ADLs) Questionnaire. Results: Multiple-regression analyses revealed that executive cognitive dysfunction and apathy scores accounted-for 44% of the variance in instrumental activities of daily living; executive cognitive dysfunction alone explained 17% of the variance in instrumental ADLs, and apathy scores explained an additional 27%. Executive dysfunction and frontal-behavioral impairment explained 28% of the variance in basic ADLs (BADLs), and, after accounting for executive dysfunction, apathy was the only symptom found to explain additional unique variance in BADLs. Conclusion: These findings suggest that specific cognitive and behavioral symptoms are associated with functional impairment in patients with AD.