Prevalence and incidence of intracranial haemorrhage in a population of children with haemophilia. The Hemophilia Growth and Development Study.
Prevalence and incidence of intracranial haemorrhage in a population of children with haemophilia. The Hemophilia Growth and Development Study.
复制标题
血友病儿童人群颅内出血的患病率和发病率。
DOI：
10.1046/j.1365-2516.1999.00338.x
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Gomperts,ED
中科院分区：
文献类型：
--
作者：
NelsonJr,MD;Maeder,MA;Usner,D;Mitchell,WG;Fenstermacher,MJ;Wilson,DA;Gomperts,ED
在我们的血友病患者群体中，颅内出血 (ICH) 的患病率为 12%。每年 ICH 的发生率约为 2%。入组时，7% (21/309) 有 ICH 临床病史，但没有陈旧性出血的 MRI 证据，这表明要么出血已完全消退，要么常规 MRI 序列对于陈旧性血液制品的检测不是特别敏感，要么是这两种因素的组合。 MRI 记录的 ICH 中有一半 (4/8) 临床无症状，MRI 记录的 11 例事件中有 3 例临床无症状。 HIV 感染不会增加脑出血的风险。
The prevalence of intracranial haemorrhage (ICH) in our population of haemophiliacs was 12%. The incidence of ICH was ≈ 2% per year. At entry, 7% (21/309) had clinical histories of ICH without MRI evidence of old haemorrhage, indicating that either the haemorrhages had completely resolved, that routine MRI sequences are not particularly sensitive for the detection of old blood products, or a combination of both of these factors. One half (4/8) of the ICHs documented by entry MRI were clinically silent, and three of the 11 incident cases documented by MRI were clinically silent. HIV infection did not increase the risk of ICH.