Waist circumference, body mass index, and postmenopausal breast cancer incidence in the Cancer Prevention Study-II Nutrition Cohort
Waist circumference, body mass index, and postmenopausal breast cancer incidence in the Cancer Prevention Study-II Nutrition Cohort
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DOI：
10.1007/s10552-014-0376-4
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发表时间：
2014-06-01
影响因子：
2.3
通讯作者：
Gapstur, Susan M.
中科院分区：
文献类型：
--
作者：
Gaudet, Mia M.;Carter, Brian D.;Gapstur, Susan M.
高体重指数（BMI）是绝经后乳腺癌的既定危险因素。然而，人们对与腰围的关系知之甚少。特别是，目前还不清楚较大的腰围与风险的相关性是否超过仅根据其对 BMI 的贡献所预期的水平。我们在癌症预防研究 II 营养队列中研究了 BMI 和腰围与绝经后乳腺癌风险的关联，无论是否进行相互调整。分析包括 28,965 名绝经后妇女，她们在 1997 年的一份问卷中报告了体重和腰围，并且没有服用绝经激素。在中位随访 11.58 年期间，发现了 1,088 例浸润性乳腺癌病例。风险比 (HR) 和 95% 置信区间 (CI) 通过多变量调整的 Cox 比例风险回归模型估算。在不调整 BMI 的情况下，较大的腰围与较高的乳腺癌风险相关（腰围每增加 10 厘米，HR = 1.13，95% CI 1.08-1.19）。然而，调整 BMI 消除了与腰围的关联（每 10 厘米 HR = 1.00，95% CI 0.92-1.08）。 BMI 与未根据腰围调整的风险相关（每 1 kg/m(2) HR = 1.04，95 % CI 1.03-1.05），并且根据腰围调整后风险相关（每 1 kg/m(2) HR = 1.04，95 % CI 1.02-1.06）。我们对以白人为主的女性进行的研究提供了证据，表明较大的腰围与绝经后乳房风险较高相关。 癌症，但不超出其对 BMI 的贡献。
High body mass index (BMI) is an established risk factor for postmenopausal breast cancer. However, less is known about associations with waist circumference. In particular, it is unclear whether a larger waist circumference is associated with risk more than would be expected based solely on its contribution to BMI.We examined the associations of BMI and waist circumference with risk of postmenopausal breast cancer, with and without mutual adjustment, in the Cancer Prevention Study-II Nutrition Cohort. Analyses included 28,965 postmenopausal women who reported weight and waist circumference on a questionnaire in 1997 and were not taking menopausal hormones.During a median follow-up of 11.58 years, 1,088 invasive breast cancer cases were identified. Hazard ratios (HR) and 95 % confidence intervals (CI) were estimated from multivariable-adjusted Cox proportional hazard regression models. Without adjustment for BMI, a larger waist circumference was associated with higher risk of breast cancer (per 10 cm increase in waist circumference, HR = 1.13, 95 % CI 1.08-1.19). However, adjustment for BMI eliminated the association with waist circumference (per 10 cm HR = 1.00, 95 % CI 0.92-1.08). BMI was associated with risk unadjusted for waist circumference (per 1 kg/m(2) HR = 1.04, 95 % CI 1.03-1.05) and adjusted for waist circumference (per 1 kg/m(2) HR = 1.04, 95 % CI 1.02-1.06).Our study of predominantly white women provides evidence that a larger waist circumference is associated with higher risk of postmenopausal breast cancer, but not beyond its contribution to BMI.