Determination of the prognostic significance of cyclin B1 overexpression in patients with esophageal squamous cell carcinoma
Determination of the prognostic significance of cyclin B1 overexpression in patients with esophageal squamous cell carcinoma
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DOI：
10.1007/s004280050319
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发表时间：
1999-02-01
期刊：
影响因子：
3.5
通讯作者：
Ogoshi, S
中科院分区：
文献类型：
--
作者：
Murakami, H;Furihata, M;Ogoshi, S
最近的研究已经确定了一个被称为细胞周期蛋白的蛋白质家族，它控制着细胞周期。细胞周期蛋白B1激活cdc2，通过G2和M期调节细胞进程。本研究的主要目的是探讨细胞周期蛋白B1在人食管鳞状细胞癌（SCC）中的表达与患者临床病理因素及预后的关系。使用抗人细胞周期蛋白B1蛋白抗体（2H1-H6）免疫组化研究了87例食管切除术后连续获得的原发性人鳞状细胞癌。并对cyclin B1表达与临床病理因素（包括预后）的关系进行统计学分析。72.4%（63/87）的肿瘤细胞免疫染色阳性，以细胞质为主；37.9%（33/87）的肿瘤细胞免疫染色呈异质性，34.5%（30/87）的肿瘤细胞免疫染色呈均匀性。浸润深度超过固有肌层的病例中，细胞周期蛋白B1的表达率明显升高(P
Recent studies have identified a family of proteins referred to as cyclins, which control the cell cycle. Cyclin B1 activates cdc2, which regulates cell progression through the G2 and M phases. The main aim of this study was to examine the relationships between the cyclin B1 expression in human esophageal squamous cell carcinoma (SCC) and clinicopathological factors and prognosis of the patients. Eighty-seven cases of primary human SCC consecutively obtained at esophagectomy were immunohistochemically studied using an anti-human cyclin B1 protein antibody (2H1-H6). The relationship between cyclin B1 expression and clinicopathological factors, including prognosis, were also statistically assessed. Positive immunostaining of cancer cells, mainly in the cytoplasm, was detected in 72.4% (63/87): heterogeneous pattern in 37.9% (33/87) and homogeneous pattern in 34.5% (30/87). The prevalence of cyclin B1 expression was significantly higher in cases with invasion deeper than the muscularis propria (P