BLOOD-PLATELET UPTAKE OF SEROTONIN IN EPISODIC AGGRESSION
BLOOD-PLATELET UPTAKE OF SEROTONIN IN EPISODIC AGGRESSION
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DOI：
10.1016/0165-1781(89)90003-6
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发表时间：
1989-01-01
影响因子：
11.3
通讯作者：
ROSE, RM
中科院分区：
文献类型：
--
作者：
BROWN, CS;KENT, TA;ROSE, RM
血小板对3h - 5 -羟色胺的摄取（5HT摄取）是血清素能功能的潜在标志，测定了15例有发作性攻击的男性门诊患者（n = 15）和年龄和性别匹配的非攻击对照组（n = 15）。对“冲动性”量表（Barratt冲动性量表，第十次修订）和“愤怒”量表（Spielberger愤怒表达量表）进行相关性分析。发作性攻击患者的平均5HT摄取降低了18%。血小板5HT摄取与冲动性评分的%差异呈显著负相关，而血小板5HT摄取与愤怒的相关性不显著。这些结果支持了攻击行为中5 -羟色胺功能紊乱的假设，并提示其主要关系在于攻击行为的“控制”。血小板可用于识别冲动性亚型。
Blood platelet uptake of 3H-serotonin (5HT uptake), a potential marker of serotonergic function, was determined in male outpatients with episodic aggression (n = 15) and in age- and sex-matched nonaggressive controls (n = 15). Correlations with rating scales of "impulsivity" (Barratt Impulsivity Scale, 10th revision) and "anger" (Spielberger Anger Expression Scale) were performed. Mean 5HT uptake was 18% lower in patients with episodic aggression. A significant negative correlation between % difference in platelet 5HT uptake and impulsivity score was observed, but the correlation between 5HT uptake and anger was not significant. These results support the hypothesis of disturbed serotonergic function in aggression and suggest that the primary relationship is in the "control" of aggression. The blood platelet may be useful in identifying impulsive subtypes.