Iron and cancer: more ore to be mined.
Iron and cancer: more ore to be mined.
复制标题
DOI：
10.1038/nrc3495
复制
发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also has the capacity to engage in redox cycling and free radical formation. Therefore, iron can contribute to both tumour initiation and tumour growth; recent work has also shown that iron has a role in the tumour microenvironment and in metastasis. Pathways of iron acquisition, efflux, storage and regulation are all perturbed in cancer, suggesting that reprogramming of iron metabolism is a central aspect of tumour cell survival. Signalling through hypoxia-inducible factor (HIF) and WNT pathways may contribute to altered iron metabolism in cancer. Targeting iron metabolic pathways may provide new tools for cancer prognosis and therapy.
登录
查看更多内容
影响因子：
3.5
作者：
Adams, BK;Ferstl, EM;Shoji, M
通讯作者：
Shoji, M
通过 5-脂氧合酶抑制剂 Garcinol 对 7,12-二甲基苯并[a]蒽 (DMBA) 诱导的仓鼠颊囊癌发生进行化学预防。
DOI：
10.1080/01635581.2012.718032
发表时间：
2012
期刊：
Nutrition and cancer
影响因子：
--
作者：
Chen X;Zhang X;Lu Y;Shim JY;Sang S;Sun Z;Chen X
通讯作者：
Chen X
影响因子：
11.5
作者：
Boult, Jessica;Roberts, Keith;Tselepis, Chris
通讯作者：
Tselepis, Chris
影响因子：
8
作者：
Coombs, G. S.;Schmitt, A. A.;Canning, C. A.;Alok, A.;Low, I. C. C.;Banerjee, N.;Kaur, S.;Utomo, V.;Jones, C. M.;Pervaiz, S.;Toone, E. J.;Virshup, D. M.
通讯作者：
Virshup, D. M.
影响因子：
24.5
作者：
Brookes, M. J.;Hughes, S.;Tselepis, C.
通讯作者：
Tselepis, C.