Being overweight increases susceptibility to indoor pollutants among urban children with asthma.
Being overweight increases susceptibility to indoor pollutants among urban children with asthma.
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DOI：
10.1016/j.jaci.2012.12.1570
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发表时间：
2013-04
影响因子：
14.2
通讯作者：
Matsui, Elizabeth C.
中科院分区：
文献类型：
--
作者：
Lu, Kim D.;Breysse, Patrick N.;Diette, Gregory B.;Curtin-Brosnan, Jean;Aloe, Charles;Williams, D'Ann L.;Peng, Roger D.;McCormack, Meredith C.;Matsui, Elizabeth C.
超重和暴露在室内污染物中都与哮喘患者的健康状况恶化有关，在城市少数民族人群中很常见。超重是否是室内污染物暴露对哮喘健康影响的风险因素尚不清楚。我们试图检验体重对城市少数民族儿童室内污染物暴露与哮喘健康的关系的影响。对148例持续性哮喘患儿(年龄5~17岁)进行为期1年的随访。每3个月评估一次哮喘症状、医疗保健使用情况、肺功能、肺部炎症和室内污染物。体重分类以体重指数百分位数为基础。参与者主要是非裔美国人(91%)，并拥有公共医疗保险(85%)。4%的人体重不足，52%的人体重正常，16%的人超重，28%的人肥胖。在一系列哮喘症状中，超重或肥胖参与者比正常体重参与者有更多与暴露于直径小于2.5μm的细颗粒物(PM2.5)相关的症状。超重或肥胖的参与者也比正常体重的参与者有更多与二氧化氮(NO2)暴露相关的哮喘症状，尽管这并不是在所有类型的哮喘症状中都能观察到。体重不影响暴露于直径在2.5至10μm之间的粗颗粒物与哮喘症状的关系。室内污染物暴露与医疗保健使用、肺功能或肺部炎症之间的关系没有因体重而异。超重或肥胖会增加城市哮喘儿童对室内PM2.5和NO2的易感性。旨在减肥的干预措施可能会减少哮喘症状对PM2.5和NO2的反应，而旨在降低室内污染物水平的干预措施可能对超重儿童特别有益。
Both being overweight and exposure to indoor pollutants, which have been associated with worse health of asthmatic patients, are common in urban minority populations. Whether being overweight is a risk factor for the effects of indoor pollutant exposure on asthma health is unknown. We sought to examine the effect of weight on the relationship between indoor pollutant exposure and asthma health in urban minority children. One hundred forty-eight children (age, 5–17 years) with persistent asthma were followed for 1 year. Asthma symptoms, health care use, lung function, pulmonary inflammation, and indoor pollutants were assessed every 3 months. Weight category was based on body mass index percentile. Participants were predominantly African American (91%) and had public health insurance (85%). Four percent were underweight, 52% were normal weight, 16% were overweight, and 28% were obese. Overweight or obese participants had more symptoms associated with exposure to fine particulate matter measuring less than 2.5 μm in diameter (PM2.5) than normal-weight participants across a range of asthma symptoms. Overweight or obese participants also had more asthma symptoms associated with nitrogen dioxide (NO2) exposure than normal-weight participants, although this was not observed across all types of asthma symptoms. Weight did not affect the relationship between exposure to coarse particulate matter measuring between 2.5 and 10 μm in diameter and asthma symptoms. Relationships between indoor pollutant exposure and health care use, lung function, or pulmonary inflammation did not differ by weight. Being overweight or obese can increase susceptibility to indoor PM2.5 and NO2 in urban children with asthma. Interventions aimed at weight loss might reduce asthma symptom responses to PM2.5 and NO2, and interventions aimed at reducing indoor pollutant levels might be particularly beneficial in overweight children.
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影响因子：
10.4
作者：
Delfino RJ;Zeiger RS;Seltzer JM;Street DH;McLaren CE
通讯作者：
McLaren CE
DOI：
10.1164/rccm.200308-1178oc
发表时间：
2004-08-15
影响因子：
24.7
作者：
Bacharier, LB;Strunk, RC;Sorkness, CA
通讯作者：
Sorkness, CA
影响因子：
9.6
作者：
Jenkins, HA;Cherniack, R;Spahn, JD
通讯作者：
Spahn, JD
影响因子：
3.8
作者：
Lang, A. M.;Konradsen, J.;Carlsen, K. C. Lodrup
通讯作者：
Carlsen, K. C. Lodrup
DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society