Bioelectrical activity of an epileptogenic focus in rat neocortex.
Bioelectrical activity of an epileptogenic focus in rat neocortex.
复制标题
大鼠新皮质致癫痫病灶的生物电活动。
DOI：
10.1016/0006-8993(73)90335-1
复制
发表时间：
1973
期刊：
影响因子：
2.9
通讯作者：
P. Maresˇ
中科院分区：
文献类型：
--
作者：
P. Maresˇ
在对45只未麻醉的雄性大鼠进行的急性实验中，记录了将青霉素应用于皮层的额叶、颞叶或枕叶区域所产生的新皮层致痫灶的生物电活动。局灶性放电的平均值是用LINC计算机根据一个程序确定的，该程序通过其幅度识别放电。无论病灶的位置如何，原发灶的放电具有相同的基本形状。唯一的区别是发现在后放电，在颞区的低发病率可能是由于较差的丘脑皮质连接在这个区域。在镜像焦点投射放电的形状以及对侧皮层的激活方式方面，发现不同区域之间存在显著差异。
In an acute experiment on 45 unanaesthetized male rats, the bioelectrical activity of a neocortical epileptogenic focus produced by the application of penicillin to the frontal, temporal or occipital region of the cortex was recorded. The mean values of focal discharges were determined with a LINC computer on the basis of a programme which identified the discharges by their amplitude. The discharges from the primary foci had the same basic shape, irrespective of the site of the focus. The only difference was found in afterdischarges, the low incidence of which in the temporal region is probably due to poorer thalamocortical connections in this zone. Marked differences were found between the various regions in the shape of the projected discharge of the mirror focus and hence, in the manner of activation of the contralateral cortex.