Application of reproductive hormone peptides for tumor targeting.
Application of reproductive hormone peptides for tumor targeting.
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DOI：
10.2174/138920111796117427
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发表时间：
2011-07
影响因子：
2.8
通讯作者：
Xiaoyan Zhang;Congjian Xu
中科院分区：
文献类型：
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作者：
Xiaoyan Zhang;Congjian Xu
靶向治疗可能是一种很有前途的抗癌方法，因为其关注的焦点是通过高选择性提高抗肿瘤药物的疗效并减少其副作用。靶向策略之一是以肿瘤特异性配体为靶向部分，携带药物进入肿瘤细胞，并以肿瘤细胞上表达的受体为靶点与多肽配体结合。生殖激素受体在正常组织中的分布相对有限，这使得将其作为靶点并将激素肽作为靶向部分用于癌症治疗成为可能。到目前为止，已经开发了许多利用生殖激素多肽进行肿瘤靶向的方法，其中一些已经进入临床试验。本文就促性腺激素释放激素、卵泡刺激素、黄体生成素、人绒毛膜促性腺激素及其受体的靶向治疗策略作一综述。
Targeted therapy may be a promising approach against cancer because its focus of attention is to enhance the efficacy and to reduce the side effects of antitumor agents through high selectivity. One of targeted strategies is to use tumor-specific ligands as targeting moieties to carry drugs into tumor cells, and use the receptors that expressed on tumor cells as target sites to bind with peptide ligands. The fact that the distributions of reproductive hormone receptors are relatively limited in normal tissues makes it possible to use them as targeted sites and use hormone peptides as targeting moieties for cancer treatment. Until now many tumor targeting approaches with reproductive hormone peptides have been developed, and some of them have been introduced into clinical trials. Here a review is given to discuss the targeted antitumor therapeutic strategies based on gonadotropin-releasing hormone, follicle-stimulating hormones, luteinizing hormone, human chorionic gonadotropin and their receptors.