Redox metabolism in mitochondria of trypanosomatids.
Redox metabolism in mitochondria of trypanosomatids.
复制标题
锥虫线粒体的氧化还原代谢。
DOI：
10.1089/ars.2012.4948
复制
发表时间：
2013
影响因子：
6.6
通讯作者：
H. Castro
中科院分区：
文献类型：
--
作者：
A. Tomás;H. Castro
意义
SIGNIFICANCE
In the single mitochondrion of protozoan trypanosomatid parasites there are several sites for the generation and elimination of reactive oxygen species (ROS), a class of molecules that exhibit a dual role in cells, either as regulatory mediators or as cytotoxic effectors.
RECENT ADVANCES
Formation of ROS in trypanosomatid mitochondria can be induced by various drug compounds. Importantly, it can also be triggered by specific physiologic stimuli, indicating that this phenomenon may occur in living parasites as well. Elimination of ROS in these organelles is attributed to the activity of two iron-dependent superoxide dismutases (FeSODs) and up to three different peroxidases (a cytochrome c peroxidase and two thiol peroxidases).
CRITICAL ISSUES
Data regarding the formation of ROS in trypanosomatid mitochondria are limited and nonsystematic. Another critical issue refers to the exact contribution of mitochondrial FeSODs and peroxidases for ROS removal, given that their antioxidant activity is not essential when abrogated individually. This suggests some level of functional overlapping or that ROS produced in mitochondria under normal conditions can be removed noncatalytically. Also still unsolved is the mechanism by which mitochondrial thiol peroxidases are regenerated to their reduced (active) form.
FUTURE DIRECTIONS
The production of intramitochondrial ROS under physiologic conditions and their implication in parasite biology should be further clarified. The relative importance of enzymatic versus nonenzymatic mechanisms for ROS elimination in trypanosomatid mitochondria also requires investigation. Simultaneous depletion of several redundant antioxidant enzymes and determination of noncatalytic antioxidants are possible ways to achieve this.
影响因子：
2.9
作者：
Ellis, HR;Poole, LB
通讯作者：
Poole, LB
影响因子：
2.9
作者：
Jasion VS;Poulos TL
通讯作者：
Poulos TL