Amination of the ortho C-H bonds by the Cu(OAc)2-mediated reaction of 2-phenylpyridines with anilines
Amination of the ortho C-H bonds by the Cu(OAc)2-mediated reaction of 2-phenylpyridines with anilines
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DOI：
10.1246/cl.2006.842
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发表时间：
2006-08-05
影响因子：
1.6
通讯作者：
Chatani, Naoto
中科院分区：
文献类型：
--
作者：
Uemura, Takeshi;Imoto, Shinya;Chatani, Naoto
2-苯基吡啶与苯胺在Cu（OAc）（2）作为促进剂存在下的反应导致2-苯基吡啶中的邻位C-H键的选择性单胺化，从而以每转化率高的产率得到胺衍生物。这是C-H键官能化为C-N键的罕见实例。
The reaction of 2-phenylpyridines with anilines in the presence of Cu(OAc)(2) as a promoter results in selective mono-amination of the ortho C-H bonds in 2-phenylpyridines to give amine derivatives in high yields per the conversion. This is the rare example of the functionalization of C-H bonds to C-N bonds.