Formal relations between Om mutants and their suppressors in Drosophila ananassae.
Formal relations between Om mutants and their suppressors in Drosophila ananassae.
复制标题
果蝇 Om 突变体与其抑制基因之间的正式关系。
DOI：
10.1093/genetics/120.4.1035
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发表时间：
1988
期刊：
影响因子：
3.3
通讯作者：
Hinton,CW
中科院分区：
文献类型：
--
作者：
Hinton,CW
与tom转座因子在三个测试基因座中的每一个上的插入相关的视神经形态（Om）突变体是由+/+/Om与+/Om和+/Om/Om与Om/Om的表型等效性定义的新型。表现为Om突变体的抑制子并且映射到至少六个基因座的突变体从与Om突变体相同的来源并且以相似的频率回收。在六个基因座中的四个上的半显性和非多效性抑制子显示缺陷眼phenes本身，并且在第五个基因座上的表型正常突变体是由隐性皱纹眼突变体代表的基因的疑似等位基因。这些和其他性质意味着，抑制基因，如可抑制的Om突变体，是新形态的，因为tom元件插入到一个假设的序列中，它们与参与眼睛发育的一组基因的其他成员共享。同时过早表达的抑制基因和抑制突变体将允许其产品的相互作用，就像在正常的发展。
Optic morphology (Om) mutants associated with insertions of the tom transposable element at each of three tested loci are neomorphs as defined by the phenotypic equivalence of +/+/Om with +/Om and of +/Om/Om with Om/Om. Mutants behaving as suppressors of Om mutants and mapping to at least six loci are recovered from the same source and in similar frequency as Om mutants. The semidominant and nonpleiotropic suppressors at four of the six loci display defective eye phenes themselves, and the phenotypically normal mutants at a fifth locus are suspected alleles of a gene represented by recessive furrowed eye mutants. These and other properties imply that the suppressors, like suppressible Om mutants, are neomorphic due to insertion of the tom element into a hypothetical sequence they share with other members of a set of genes involved in development of the eye. Concurrently premature expression of both the suppressor and suppressed mutants would allow interaction of their products just as in normal development.