Short sequence repeats of the intergenic spacer regions of ribosomal RNA genes in Malassezia globosa and Malassezia restricta colonizing the scalps of male individuals with and without androgenetic alopecia.
Short sequence repeats of the intergenic spacer regions of ribosomal RNA genes in Malassezia globosa and Malassezia restricta colonizing the scalps of male individuals with and without androgenetic alopecia.
复制标题
球形马拉色菌和限制马拉色菌核糖体 RNA 基因基因间间隔区的短序列重复，定植于患有和不患有雄激素性脱发的男性个体的头皮上。
DOI：
10.1111/1348-0421.12979
复制
发表时间：
2022
影响因子：
2.6
通讯作者：
Sugita T
中科院分区：
文献类型：
--
作者：
Suzuki K;Cho O;Nagahama T;Sugita T
我们分析了在雄激素性脱发（阿加）中主要定植于头皮的球形马拉色菌和局限马拉色菌核糖体RNA基因的基因间间隔区（IGS）区域1的短序列重复序列（SSR）。在M中未发现阿加特异性SSR。globosaIGS区，而（CT）6：（AT）8 SSR主要在M。阿加组患者头皮的马拉色菌集落形成率较高。限制性（CT）6：（AT）8 SSR阳性率明显高于无M者。restricta（CT）6：（AT）8SSR。这些观察结果表明，这种特殊的SSR类型在M。限制性参与阿加的发展或恶化。
We analyzed the short sequence repeats (SSRs) of the intergenic spacer (IGS) region 1 of the ribosomal RNA genes inMalassezia globosaandMalassezia restricta, which predominantly colonize the scalp in androgenetic alopecia (AGA). No AGA‐specific SSRs were found in theM. globosaIGS region, whereas a (CT)6:(AT)8SSR was predominantly detected in theM. restrictaIGS region in the AGA group.Malasseziacolonization was higher in the scalps of patients withM. restricta(CT)6:(AT)8SSRs than in the scalps of patients withoutM. restricta(CT)6:(AT)8SSRs. These observations suggest that this specific SSR type inM. restrictais involved in the development or exacerbation of AGA.