β-Lactamase-non-producing ampicillin-resistant Haemophilus influenzae is acquiring multidrug resistance
β-Lactamase-non-producing ampicillin-resistant Haemophilus influenzae is acquiring multidrug resistance
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DOI：
10.1016/j.jiph.2019.11.003
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发表时间：
2020-04-01
影响因子：
6.7
通讯作者：
Noguchi, Norihisa
中科院分区：
文献类型：
--
作者：
Yamada, Shogo;Seyama, Shoji;Noguchi, Norihisa
背景：日本出现了对抗菌剂敏感性降低的流感嗜血杆菌菌株。本研究旨在了解流感嗜血杆菌对β-内酰胺类和非β-内酰胺类抗生素的不敏感性。方法：对2013-2016年间临床分离的260株流感嗜血杆菌进行分析。通过测定最小抑菌浓度来评估药物敏感性。结果：不产β-内酰胺酶的耐氨苄西林流感嗜血杆菌(BLNAR)菌株自2014年以来显著增加，占所有菌株的50%以上。此外，喹诺酮类低敏感菌株的比例显著增加(P<；0.05)。其中，3株喹诺酮类药物敏感菌株的最低抑菌浓度高于左氧氟沙星的最低抑菌浓度。此外，三株显示多重耐药的菌株中，有一株对大环内酯类、β-内酰胺类和喹诺酮类药物耐药。对非β-内酰胺类抗生素的低敏感性与BLNAR显著相关。结论：本研究提示BLNAR菌株呈上升趋势，并呈多重耐药趋势。此外，出现了多药耐药流感嗜血杆菌(MDRHI)。为了防止MDRHI的进一步传播，应评估BLNAR菌株的比例。(C)2019年提交人(S)。由爱思唯尔有限公司代表沙特国王本·阿卜杜勒阿齐兹健康科学大学出版。
Background: Haemophilus influenzae strains with reduced susceptibilities to antimicrobial agents have emerged in Japan. Here, we aimed to investigate H. influenzae non-susceptibility to beta-lactams and non-beta-lactams.Methods: A total of 260 H. influenzae isolates from patients in 2013-2016 were analysed. Antimicrobial susceptibilities were assessed by determining the minimum inhibitory concentration. Additionally, isolates with reduced susceptibility were analysed by both genetic and statistical methods.Results: beta-Lactamase-non-producing ampicillin-resistant H. influenzae (BLNAR) strains increased significantly and accounted for more than 50% of all isolates from 2014. Additionally, the proportion of quinolone-low-susceptibility isolates increased significantly (P < 0.05). Among these, three quinolonenon-susceptible isolates showed minimum inhibitory concentrations higher than the susceptibility breakpoint of levofloxacin. Moreover, one of the three isolates showing multidrug resistance was resistant to macrolides, beta-lactams, and quinolones. Low susceptibilities to non-beta-lactams were significantly associated with BLNAR.Conclusions: The present study indicates that BLNAR strains are increasing and tend to show multidrug resistance. Additionally, multidrug-resistant H. influenzae (MDRHI) has emerged. To prevent the further spread of MDRHI, the proportions of BLNAR strains should be evaluated. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.