Vestibular signals in primate thalamus: Properties and origins
Vestibular signals in primate thalamus: Properties and origins
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DOI：
10.1523/jneurosci.3931-07.2007
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发表时间：
2007-12-12
影响因子：
5.3
通讯作者：
Angelaki, Dora E.
中科院分区：
文献类型：
--
作者：
Meng, Hui;May, Paul J.;Angelaki, Dora E.
前庭激活被发现在不同的皮质区。为了表征提供给皮层的信号的途径和类型，我们记录了猕猴丘脑对旋转和/或平移刺激的反应。少数细胞单独对旋转反应，大多数细胞显示半规管和耳石信号之间的会聚。在正弦旋转期间，丘脑响应在0.01-4 Hz之间的频率下平均导致头部速度接近30度。在翻译过程中，神经元编码线性加速度和速度的组合。在一般情况下，丘脑的反应是相似的前庭和小脑核使用相同的测试范式记录，但不同的前庭传入。丘脑的反应是一个有偏见的连续：大多数细胞更强烈的编码翻译和较少的细胞调制主要是响应净重力惯性加速度。反应神经元分散在一个大的区域内，包括腹后核和腹外侧核的区域，因此不限于已知的前庭核投射区。为了确定这些反应的起源，逆行示踪剂被注射到背外侧丘脑网站旋转/偏转敏感的细胞遇到。这种注射标记的神经元在嘴侧对侧前间和顶核，但没有标记细胞内的前庭核。检查后，示踪剂注射到小脑和前庭核的丘脑终端表明，大多数前庭反应单位属于这些核的丘脑终端区。因此，从前庭核和小脑核供应到丘脑的前庭信号被定位为分布到广泛的皮质区。
Vestibular activation is found in diverse cortical areas. To characterize the pathways and types of signals supplied to cortex, we recorded responses to rotational and/or translational stimuli in the macaque thalamus. Few cells responded to rotation alone, with most showing convergence between semicircular canal and otolith signals. During sinusoidal rotation, thalamic responses lead head velocity by similar to 30 degrees on average at frequencies between 0.01-4 Hz. During translation, neurons encoded combinations of linear acceleration and velocity. In general, thalamic responses were similar to those recorded in the vestibular and cerebellar nuclei using identical testing paradigms, but differed from those of vestibular afferents. Thalamic responses represented a biased continuum: most cells more strongly encoded translation and fewer cells modulated primarily in response to net gravitoinertial acceleration. Responsive neurons were scattered within a large area that included regions of the ventral posterior and ventral lateral nuclei, and so were not restricted to the known vestibular nuclei projection zones. To determine the origins of these responses, a retrograde tracer was injected into a dorsolateral thalamic site where rotation/translation-sensitive cells were encountered. This injection labeled neurons in the rostral contralateral anterior interposed and fastigial nuclei, but did not label cells within the vestibular nuclei. Examination of thalamic terminations after tracer injections into the cerebellar and vestibular nuclei indicated that most vestibular responsive units fall within the thalamic terminal zones of these nuclei. Thus, vestibular signals, which are supplied to the thalamus from both vestibular and cerebellar nuclei, are positioned for distribution to widespread cortical areas.