Kinetic Analysis of 125 I-Iodorotenone as a Deposited Myocardial Flow Tracer: Comparison with 99m Tc-Sestamibi
Kinetic Analysis of 125 I-Iodorotenone as a Deposited Myocardial Flow Tracer: Comparison with 99m Tc-Sestamibi
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发表时间：
2001
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通讯作者：
R. Marshall;P. Powers-Risius;B. Reutter;Scott E. Taylor;H. VanBrocklin;R. Huesman;T. Budinger
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作者：
R. Marshall;P. Powers-Risius;B. Reutter;Scott E. Taylor;H. VanBrocklin;R. Huesman;T. Budinger
The goal of this investigation was to assess the accuracy of 7 9 - Z -[ 125 I]iodorotenone ( 125 I-iodorotenone) as a new deposited myocardial flow tracer and compare the results with those for 99m Tc-sestamibi. Methods: The kinetics of these two flow tracers were evaluated in 25 isolated, erythrocyte- and albumin-perfused rabbit hearts over a flow range relevant to patients. The two flow tracers and a vascular reference tracer ( 131 I-albu-min) were introduced simultaneously as a compact bolus through a port just above the aortic cannula in the absence of tracer recirculation. Myocardial extraction, retention, washout, and uptake parameters were computed from the venous outflow curves using the multiple-indicator dilution technique and spectral analysis. Results: The extraction of 125 I-iodorotenone was much higher than the extraction of 99m Tc-sestamibi (0.84 6 0.05 vs. 0.48 6 0.10, respectively, P , 0.001). 125 I-iodorotenone extraction was also less affected by flow than was 99m Tc-ses-tamibi ( P , 0.001). Net retention of 125 I-iodorotenone was significantly greater than 99m Tc-sestamibi net retention at 1 min (0.77 6 0.08 vs. 0.41 6 0.11, respectively, P , 0.001) and 26 min (0.46 6 0.13 vs. 0.27 6 0.11, respectively, P , 0.001) after tracer injection. Flow had less effect on 125 I-iodorotenone net retention than on 99m Tc-sestamibi net retention 1 min after tracer injection ( P , 0.04). However, at 26 min, flow had an equivalent effect on the retention of both flow tracers ( P , 0.4). The relationship between 125 I-iodorotenone and 99m Tc-sestamibi washout was complex and depended on elapsed time after isotope introduction and perfusion rate. Reflecting the favorable extraction and retention characteristics of 125 I-iodorotenone, both its maximum myocardial uptake and its 26-min uptake were more closely related to flow than were those of 99m Tc-sestamibi ( P , 0.001 for both comparisons). Conclusion: The extraction and retention of 125 I-iodorotenone were greater than those of 99m Tc-sestamibi, making 125 I-iodorotenone the superior flow tracer in the isolated rabbit heart.
