Functional photoacoustic imaging to observe regional brain activation induced by cocaine hydrochloride.
Functional photoacoustic imaging to observe regional brain activation induced by cocaine hydrochloride.
复制标题
功能性光声成像观察盐酸可卡因诱导的区域脑激活。
DOI：
10.1117/1.3626576
复制
发表时间：
2011
影响因子：
3.5
通讯作者：
Yang,Xinmai
中科院分区：
文献类型：
--
作者：
Jo,Janggun;Yang,Xinmai
光声显微镜（PAM）用于检测小动物大脑对药物滥用的反应。通过尾静脉将盐酸可卡因盐水溶液注射到 Sprague Dawley 大鼠的血流中。然后通过 PAM 技术监测大鼠大脑响应药物注射的功能变化。获得大鼠大脑在前囟后 1.2 和 3.4 mm 位置处的冠状视图图像。所得光声（PA）图像显示了血容量的区域变化。此外，还介绍了血氧的区域变化。结果表明，PA 成像能够监测药物滥用引起的局部血流动力学变化。
Photoacoustic microscopy (PAM) was used to detect small animal brain activation in response to drug abuse. Cocaine hydrochloride in saline solution was injected into the blood stream of Sprague Dawley rats through tail veins. The rat brain functional change in response to the injection of drug was then monitored by the PAM technique. Images in the coronal view of the rat brain at the locations of 1.2 and 3.4 mm posterior to bregma were obtained. The resulted photoacoustic (PA) images showed the regional changes in the blood volume. Additionally, the regional changes in blood oxygenation were also presented. The results demonstrated that PA imaging is capable of monitoring regional hemodynamic changes induced by drug abuse.