Induction of intestinal tumors in rats by dextran sulfate sodium.
Induction of intestinal tumors in rats by dextran sulfate sodium.
复制标题
右旋糖酐硫酸钠诱导大鼠肠道肿瘤。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
L. Golberg
中科院分区：
文献类型：
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作者：
I. Hirono;K. Kuhara;S. Hosaka;S. Tomizawa;L. Golberg
研究了硫酸葡聚糖钠对近交ACI大鼠的致癌性。1组，10只雄性大鼠饲喂10%葡聚糖硫酸钠日粮；2组，雄性大鼠14只，雌性大鼠12只，饲喂5%葡聚糖硫酸钠日粮；对照组9只雄性大鼠和9只雌性大鼠分别饲喂不含硫酸葡聚糖钠的基础日粮。饲喂方案开始后，饲喂10%葡聚糖硫酸钠的大鼠均在14天内死于严重腹泻和贫血，饲喂5%葡聚糖硫酸钠的23只存活大鼠中有15只在134 ~ 215天内出现肠道肿瘤。这些肿瘤是在结肠和盲肠诱导的，包括腺瘤、腺癌和乳头状瘤。
The carcinogenicity of dextran sulfate sodium was studied in inbred ACI rats. In group 1, 10 male rats were fed a 10% dextran sulfate sodium diet; in group 2, 14 male and 12 female rats were fed a 5% dextran sulfate sodium diet; and in the control group, 9 male and 9 female rats were given the basal diet without dextran sulfate sodium. After the start of the feeding regimen, all rats given the 10% dextran sulfate sodium diet died of severe diarrhea and anemia within 14 days and 15 of 23 surviving rats fed a 5% dextran sulfate sodium diet developed intestinal tumors between 134 and 215 days. These tumors were induced in the colon and cecum and consisted of adenomas, adenocarcinomas, and papillomas.