The association of diabetes with colorectal cancer risk: the Multiethnic Cohort.
The association of diabetes with colorectal cancer risk: the Multiethnic Cohort.
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DOI：
10.1038/sj.bjc.6605721
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发表时间：
2010-06-29
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
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研究发现，糖尿病患者患结直肠癌的风险比非糖尿病患者更高。我们在基于人群的前瞻性队列中检验了这种关系是否因种族、癌症部位或肿瘤分期而不同，包括在13年期间(1993年至2006年)在多种族队列中发现的199 143名欧洲裔美国人、非裔美国人、夏威夷原住民、日裔美国人和拉美裔男性和女性中发现的3,549例结直肠癌病例。总体而言，糖尿病患者患结直肠癌的风险显著高于非糖尿病患者(相对风险(RR)=1.19，95%可信区间(CI)=1.091.29，P值(P)&0.001)。观察到结肠癌、右半结肠和左半结肠癌，以及在局部和局部/远距离阶段诊断的癌症之间存在正相关。吸烟状况对结直肠癌风险的影响有统计学意义(P=0.0044)，不吸烟者的RR(RR=1.32，95%CI=1.15~1.53，P<；0.001)高于既往吸烟者(RR=1.19，95%CI=1.05~1.34，P=0.007)和现吸烟者(RR=0.9，95%CI=0.70~1.15，P=0.4)。这些发现有力地支持了糖尿病是结直肠癌风险因素的假设。
Diabetics have been found to have a greater risk of colorectal cancer than non-diabetics. We examined whether this relationship differed by ethnic group, cancer site or tumour stage in a population-based prospective cohort, including 3549 incident colorectal cancer cases identified over a 13-year period (1993–2006) among 199 143 European American, African American, Native Hawaiian, Japanese American and Latino men and women in the Multiethnic Cohort. Diabetics overall had a significantly greater risk of colorectal cancer than did non-diabetics (relative risk (RR)=1.19, 95% confidence interval (CI)=1.09–1.29, P-value (P)<0.001). Positive associations were observed for colon cancer, cancers of both the right and left colon, and cancers diagnosed at a localised and regional/distant stage. The association with colorectal cancer risk was significantly modified by smoking status (PInteraction=0.0044), with the RR being higher in never smokers (RR=1.32, 95% CI=1.15–1.53, P<0.001) than past (RR=1.19, 95% CI=1.05–1.34, P=0.007) and current smokers (RR=0.90, 95% CI=0.70–1.15, P=0.40). These findings provide strong support for the hypothesis that diabetes is a risk factor for colorectal cancer.
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影响因子：
8.8
作者：
Nilsen TI;Vatten LJ
通讯作者：
Vatten LJ
影响因子：
29.4
作者：
Schoen, RE;Weissfeld, JL;Rosen, CJ
通讯作者：
Rosen, CJ
影响因子：
6.4
作者：
Jenab, Mazda;Riboli, Elio;Kaaks, Rudolf
通讯作者：
Kaaks, Rudolf
影响因子：
5
作者：
Will, JC;Galuska, DA;Calle, EE
通讯作者：
Calle, EE
影响因子：
10.3
作者：
Hu, FB;Manson, JE;Giovannucci, E
通讯作者：
Giovannucci, E