COMPOSITION OF HUMAN SALIVA - PAROTID GLAND SECRETORY RATE AND ELECTROLYTE CONCENTRATION IN CHILDREN WITH CYSTIC FIBROSIS
COMPOSITION OF HUMAN SALIVA - PAROTID GLAND SECRETORY RATE AND ELECTROLYTE CONCENTRATION IN CHILDREN WITH CYSTIC FIBROSIS
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DOI：
10.1016/0003-9969(62)90119-x
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发表时间：
1962-01-01
影响因子：
3
通讯作者：
KULCZYEKI, LL
中科院分区：
文献类型：
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作者：
CHAUNCEY, HH;LEVINE, DM;KULCZYEKI, LL
对31例健康儿童和29例囊性纤维化儿童的腮腺唾液分泌率和电解质进行了测定。以风味乳胶为刺激剂，用真空杯收集未受污染的腮腺液。结果数据显示，两组之间的分泌率、pH、钾和碳酸氢值没有显著差异。虽然纤维囊肿症患者唾液中的钠和氯浓度较高，但患者和对照组之间的差异仅具有“边缘”意义。纤维囊肿组的钙、磷水平显著升高。将对照组和纤维囊肿组细分后(用分泌率的中位数来划分各组)，正常儿童和纤维囊肿组儿童唾液钠浓度在低分泌率时差异有统计学意义。无论是低流速还是高流速，囊性纤维症患儿的唾液钙浓度均显着高于正常组。正常组和纤维囊性疾病组之间的磷浓度仅在分泌率中位数以上的亚组有显着性差异。目前研究中获得的信息似乎表明，囊性纤维化儿童的腮腺导管细胞代谢存在缺陷。据推测，导管细胞不能像正常儿童那样重新吸收钠，并分泌过量的钙和磷。
Parotid saliva secretion rate and electrolyte composition were determined in thirty-one healthy children and twenty-nine children with cystic fibrosis. Flavored chicle was used as the stimulatory agent, and the un-contaminated parotid fluid was collected by means of a vacuum cup. The resultant data indicated that there were no significant differences in the secretion rate, pH, potassium and bicarbonate values between the groups. Although higher sodium and chloride concentrations were noted in the saliva obtained from the fibrocystic patients, the difference between the patient and control groups was only of "borderline" significance. Calcium and phosphorus levels were significantly elevated in the fibrocystic group. After subdivision of the control and fibrocystic groups (using the median secretion rate to divide each group) there was a statistically significant difference in the salivary sodium concentration between normal and fibrocystic children at low rates of secretion. At both low and high flow rates the salivary calcium concentration of the children with cystic fibrosis was significantly higher than the levels observed for the normal group. There was a significant difference in phosphorus concentration between normal and fibrocystic patients only in the subgroups above the median secretion rate. Information obtained in the current study seems to indicate that a defect exists in the metabolism of the parotid gland duct cells in children with cystic fibrosis. Presumably the duct cells fail to reabsorb sodium to the extent observed in normal children and secrete excessive amounts of calcium and phosphorus.