Altered Expression of Sialidases in Human Cancer
Altered Expression of Sialidases in Human Cancer
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DOI：
10.1007/978-1-4614-3381-1_17
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Shiozaki, K.
中科院分区：
文献类型：
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作者：
Miyagi, Taeko;Takahashi, K.;Shiozaki, K.
唾液酸酶是一种糖苷酶，它催化从糖蛋白和糖脂的碳水化合物基团中去除α-糖基连接的唾液酸残基，这是糖结合物降解的第一步。根据主要的亚细胞定位和酶性质，已经鉴定、表征和命名了四种类型的人唾液酸酶：NEU1、NEU2、NEU3和NEU4。每个唾液酸酶都被发现根据其特定的性质发挥着独特的作用。本文主要对我们在人类唾液酸酶在癌症中的异常表达和病理作用的最新研究结果作一简要综述。
Sialidases are glycosidases catalyzing the removal of α-glycosidically linked sialic acid residues from carbohydrate groups of glycoproteins and glycolipids, which is the initial step in degradation of the glycoconjugates. Four types of human sialidases have been identified, characterized, and designated as NEU1, NEU2, NEU3, and NEU4, according to their major subcellular localization and enzymatic properties. Each sialidase has been found to play a unique role depending on its particular properties. The present review briefly summarizes mainly our recent results on aberrant expression and pathological roles of human sialidases in cancer.