Remote-site stimulation of secretory IgA antibodies following bronchial and gastric stimulation.
Remote-site stimulation of secretory IgA antibodies following bronchial and gastric stimulation.
复制标题
支气管和胃刺激后远程刺激分泌型 IgA 抗体。
DOI：
10.1007/978-1-4684-3369-2_14
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发表时间：
1978
影响因子：
--
通讯作者：
C. A. Skandera
中科院分区：
文献类型：
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作者：
P. C. Montgomery;K. M. Connelly;J. Cohn;C. A. Skandera
分泌性抗体的诱导仍然是一个复杂的课题，有多种因素是重要的：1）动物模型的选择，2）抗原刺激的性质和3）免疫方法。我们自己的研究已经利用孕兔和各种DNP-载体结合物来探测分泌性抗体，特别是分泌性伊加在乳腺中被诱导的方式（1-3）。这些研究表明：1）本地（乳房内）抗原给药可有效地重复诱发s-IgA抗体，（证实了早期的研究（4，5），2）高水平s-IgA抗体的诱导和血清IgG抗体之间缺乏相关性，3）胃肠刺激和远端（乳房）s-IgA抗体产生之间似乎存在特殊关系，和4）乳中s-IgA抗体的胃肠道刺激不被高水平的循环IgG血清抗体阻断。其他证据表明，类似的“远程站点”刺激现象也存在于其他动物物种中。
The induction of secretory antibodies remains a complex subject with a variety of factors being important: 1) choice of the animal model, 2) the nature of the antigenic stimulus and 3) the method of immunization. Our own investigations have utilized the pregnant rabbit and various DNP-carrier conjugates to probe the manner by which secretory antibodies, particularly secretory (s) IgA, were induced in mammary glands (1–3). These studies demonstrated that: 1) local (intramammary) administration of antigen was effective at reproducibly eliciting s-IgA antibodies (confirming earlier studies (4,5), 2) there was a lack of correlation between the induction of high levels of s-IgA antibodies and serum IgG antibodies, 3) there appeared to be a special relationship between gastrointestinal stimulation and remote-site (mammary) production of s-IgA antibodies, and 4) gastrointestinal stimulation of s-IgA antibodies in milk was not blocked by high levels of circulating IgG serum antibodies. Additional evidence suggested that a similar “remote-site” stimulation phenomenon also existed in other animal species.