Non-ribosomal factors in ribosome subunit assembly are emerging targets for new antibacterial drugs
Non-ribosomal factors in ribosome subunit assembly are emerging targets for new antibacterial drugs
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DOI：
10.1016/j.coph.2006.05.005
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发表时间：
2006-10-01
影响因子：
4
通讯作者：
Brown, Eric D.
中科院分区：
文献类型：
--
作者：
Comartin, David J.;Brown, Eric D.
越来越清楚的是，细菌核糖体组装是由多种非核糖体因子催化的。细菌核糖体生物合成中的新特征因子是广泛保守的并且通常是不可或缺的蛋白质，其可以被分类为促进组装的分子伴侣，或具有核糖体RNA和核糖体蛋白修饰功能的酶。越来越多的证据表明，蛋白质Era，Obg，YjeQ，YlqF和RimM是分子伴侣，它们可能对细菌核糖体组装至关重要，因此代表了现代抗菌药物发现的新靶点。正在进行的旨在了解核糖体生物发生的工作预计将继续产生对这一过程至关重要的其他因素，并提供具有药物发现潜力的新靶点。
It is becoming increasingly clear that bacterial ribosome assembly is catalyzed by a variety of non-ribosomal factors. Newly characterized factors in bacterial ribosome biogenesis are broadly conserved and often indispensable proteins that can be classified either as chaperones facilitating assembly, or enzymes with ribosomal RNA- and ribosomal protein-modifying functions. Accumulating evidence indicates that the proteins Era, Obg, YjeQ, YlqF and RimM are chaperones which may be crucial to bacterial ribosome assembly, and therefore represent novel targets for modern antibacterial drug discovery. Ongoing work aimed at understanding ribosome biogenesis is expected to continue to yield additional factors crucial to this process, and provide new targets with drug discovery potential.