Polymorphisms of caprine PrP gene detected in Japan
Polymorphisms of caprine PrP gene detected in Japan
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DOI：
10.1292/jvms.67.321
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发表时间：
2005-03-01
影响因子：
1.2
通讯作者：
Shinagawa, M
中科院分区：
文献类型：
--
作者：
Kurosaki, Y;Ishiguro, N;Shinagawa, M
PrP基因多态性是影响绵羊和山羊自然和实验性瘙痒症易感性和潜伏期的主要因素。在118只山羊中检测了日本山羊PrP基因的多态性。共获得8个等位基因变异体和19种基因型。在102、142、143、240、127、146和211这7个密码子上观察到氨基酸多态性（后3个是新的多态性）。与羊痒病抗性相关的密码子142M和143R的多态性在本研究中相对较少。因此，本研究结果提供了山羊PrP基因的信息，可能是有用的山羊瘙痒症的风险评估。
Polymorphism of the PrP gene is a primary factor influencing susceptibility and incubation period in natural and experimental scrapie in sheep and goats. Polymorphisms of the caprine PrP gene in Japan were examined in 118 goats. Eight allelic variants and 19 genotypes were obtained. Amino acid polymorphisms were observed at 7 codons: 102, 142, 143, 240, 127, 146 and 211 (the latter 3 are novel polymorphisms). The polymorphisms at codons 142M and 143R, which are associated with the resistance to scrapie, were relatively rare in the present study. Thus, the present results provide information about the caprine PrP gene that may be useful for assessing the risk of goat scrapie.