Unconventional myosins in muscle
Unconventional myosins in muscle
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DOI：
10.1016/j.ejcb.2007.05.007
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发表时间：
2007-09-01
影响因子：
6.6
通讯作者：
Redowicz, Maria Jolanta
中科院分区：
文献类型：
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作者：
Redowicz, Maria Jolanta
肌球蛋白是最初从肌肉组织中分离出来的基于肌动蛋白的分子马达，在所有真核细胞中普遍表达。它们参与多种细胞功能，包括细胞迁移、细胞内运输、黏附以及胞质分裂。在生肌细胞和/或成年肌肉中已经检测到几种属于第1、5、6、7、9和18类的非传统肌球蛋白，它们似乎在肌肉功能和/或分化中起重要作用。例如，肌球蛋白6基因内的一个点突变会导致心脏功能障碍，而肌球蛋白18B（主要在横纹肌中表达）可能参与肌肉基因转录。这篇综述总结了有关这些非传统肌球蛋白在肌肉和/或生肌细胞中功能的数据。（c）2007爱思唯尔有限公司。保留所有权利。
Myosins, actin-based molecular motors originally isolated from muscle tissues, are ubiquitously expressed in all eukaryotic cells. They are involved in a panoply of cellular functions, including cell migration, intracellular trafficking, adhesion, and cytokinesis. Several unconventional myosins belonging to classes 1, V, VI, VII, IX, and XVIII have been detected in myogenic cells and/or adult muscle where they seem to play important roles in muscle functioning and/or differentiation. For example, a point mutation within the myosin VI gene leads to a cardiac dysfunction, and myosin XVIIIB (expressed predominantly in striated muscle) may be involved in muscle gene transcription. This review summarizes data addressing the functioning of these unconventional myosins in muscle and/or myogenic cells. (c) 2007 Elsevier GmbH. All rights reserved.