Deafferentation studies on the glutamic acid decar☐ylase content of the supraoptic nucleus of the rat
Deafferentation studies on the glutamic acid decar☐ylase content of the supraoptic nucleus of the rat
复制标题
大鼠视上核谷氨酸脱羧酶含量的传入阻滞研究
DOI：
10.1016/0006-8993(80)91102-6
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发表时间：
1980
期刊：
影响因子：
2.9
通讯作者：
M. Brownstein
中科院分区：
文献类型：
--
作者：
D. K. Meyer;W. Oertel;M. Brownstein
对向视上核发出传出纤维的GABA能神经元的定位进行了研究。为此，我们测定了GABA能神经元的特异性标记物--谷氨酸脱氢☐酰化酶在视上核中的活性。切断来自中脑和下丘脑内侧基底的纤维以及来自海马体的纤维没有影响。然而，当海人酸注入伏核时，损毁视上核使其谷氨酸降解☐水解酶的活性降低约40%。因此，视上核中的神经元似乎从伏隔核接受了大部分GABA能传入。此外，视上核内部或邻近的GABA能神经元似乎有助于调节加压素和/或催产素的释放。
The localization of the GABAergic neurons which send efferent fibers to the supraoptic nucleus was investigated. For this purpose the activity of glutamic acid decar☐ylase, a specific marker for GABAergic neurons, was determined in the supraoptic nucleus after a variety of lesions. The severance of fibers from the mesencephalon and the mediobasal hypothalamus, as well as from the hippocampus, had no effect. However, lesions rostral to the nucleus reduced its activity in glutamic acid decar☐ylase by about 40%, as did the infusion of kainic acid into the nucleus accumbens.Thus, the neurons in the supraoptic nucleus seem to receive a large part of their GABAergic afferents from the n. accumbens. In addition to that, GABAergic neurons intrinsic or adjacent to the supraoptic nucleus seem to contribute to the regulation of the release of vasopressin and/or oxytocin.