Large-scale remapping of visual cortex is absent in adult humans with macular degeneration
Large-scale remapping of visual cortex is absent in adult humans with macular degeneration
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DOI：
10.1038/nn.2793
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发表时间：
2011-05-01
影响因子：
25
通讯作者：
Morland, Antony B.
中科院分区：
文献类型：
--
作者：
Baseler, Heidi A.;Gouws, Andre;Morland, Antony B.
枕叶包含视野的视网膜异位表征。早期视觉区（V1-3）的中央视网膜表现在枕极。当两只眼睛的中央视网膜因黄斑变性而受损时，枕极视觉皮层的这一区域相应被剥夺了输入。然而，即使这种病变发生在成年期，也可以观察到枕极内和周围的一些视觉驱动的活动。有人认为，这种活动是该区域重新映射的结果，因此它现在对来自完整的外围视网膜的输入作出反应。我们评估了视觉皮层的重新映射是否在这种活动的基础上。我们的功能性磁共振成像结果没有提供重新定位的证据，质疑当代的观点，即成人大脑的早期视觉区域具有广泛重组的能力。
The occipital lobe contains retinotopic representations of the visual field. The representation of the central retina in early visual areas (V1-3) is found at the occipital pole. When the central retina is lesioned in both eyes by macular degeneration, this region of visual cortex at the occipital pole is accordingly deprived of input. However, even when such lesions occur in adulthood, some visually driven activity in and around the occipital pole can be observed. It has been suggested that this activity is a result of remapping of this area so that it now responds to inputs from intact, peripheral retina. We evaluated whether or not remapping of visual cortex underlies this activity. Our functional magnetic resonance imaging results provide no evidence of remapping, questioning the contemporary view that early visual areas of the adult human brain have the capacity to reorganize extensively.