Supramolecular Porphyrin Photosensitizers: Controllable Disguise and Photoinduced Activation of. Antibacterial Behavior
Supramolecular Porphyrin Photosensitizers: Controllable Disguise and Photoinduced Activation of. Antibacterial Behavior
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DOI：
10.1021/acsami.7b02611
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发表时间：
2017-04-26
影响因子：
9.5
通讯作者：
Zhang, Xi
中科院分区：
文献类型：
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作者：
Chen, Linghui;Bai, Haotian;Zhang, Xi
基于主客体相互作用，由含有季铵基团的卟啉衍生物（Por）与葫芦[7]脲（CB[7]）制备了一系列超分子光敏剂。 Por在黑暗中与CB结合后可以关闭抗菌活性[7]，而在白光照射下可以开启抗菌活性。此外，通过引入金属离子可以大大提高其抗菌效率。当卟啉中引入Pd(II)后，其抗菌效率从40%提高到100%。应该指出的是，即使浓度高于所研究的抗菌条件下的浓度，这些小分子对哺乳动物细胞也几乎没有显示出细胞毒性。该研究将为由季铵基团组成的杀菌剂提供长期对抗细菌积累的策略，并在现实世界中具有巨大的应用潜力。
A series of supramolecular photosensitizers were fabricated from porphyrin derivatives (Por) containing quaternary ammonium groups with cucurbit[7]uril (CB[7]) based on host guest interactions. The antibacterial activity of Por in the dark could be turned off upon binding with CB[7], whereas the antibacterial activity under white-light illumination could be turned on. In addition, its antibacterial efficiency could be greatly enhanced by introducing metal ions. When Pd(II) was introduced into porphyrin, its antibacterial efficiency was enhanced from 40 to 100%. It should be noted that these small molecules showed little to no cytotoxicity toward mammalian cells even at concentrations higher than those under the antibacterial condition studied. This line of research will provide a strategy for germicides consisting of quaternary ammonium groups to fight against bacterial accumulation in the long term and holds huge potential for application in the real world.