Effect of propofol on the electrocorticogram in epileptic patients undergoing cortical resection
Effect of propofol on the electrocorticogram in epileptic patients undergoing cortical resection
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DOI：
10.1093/bja/82.2.199
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发表时间：
1999-02-01
影响因子：
9.8
通讯作者：
Binnie, CD
中科院分区：
文献类型：
--
作者：
Hewitt, PB;Chu, DLK;Binnie, CD
我们比较了临床剂量异丙酚和硫喷妥钠对20例接受颞叶切除术的癫痫患者皮层脑电活动的影响。在获得基线ECoG后，受试者被随机分配到硫喷妥钠25 mg或丙泊酚20 mg静脉注射，吸入浓度为0.5-1%异氟醚和70%一氧化二氮作为背景麻醉。S每30次给药，最大剂量为5毫克/公斤(-1)，直至出现猝发抑制。在整个给药过程中记录ECoG，此后记录10分钟。在基线ECoG描记恢复后，给予替代药物。癫痫样活动的量被记录在有序的分级量表上，增加的指示要么是量表上至少一个类别的上升，要么是至少一个新部位的放电。硫喷妥钠的激活频率更高，但差异不显着。这项研究表明，异丙酚的异丙酚并不比硫喷妥钠更有效，硫喷妥钠是一种常用于控制癫痫持续状态的药物。
We have compared the effect of clinical doses of propofol with thiopental on epileptiform activity in the electrocorticograms (ECoG) of 20 epileptic patients undergoing temporal lobe resection. After baseline ECoG had been obtained, with inspired concentrations of 0.5-1% isoflurane and 70% nitrous oxide to provide background anaesthesia, subjects were allocated randomly to receive boluses of either thiopental 25 mg or propofol 20 mg i.v. every 30 s to a maximum of 5 mg kg(-1) or until burst suppression was seen. The ECoG was recorded throughout administration and for 10 min thereafter. After return of baseline ECoG tracings, the alternate agent was administered. The amount of epileptiform activity was recorded on an ordinal rating scale, an increase being indicated by either a rise of at least one category on the scale or discharges occurring at a minimum of one new site. Activation occurred more frequently with thiopental but the difference was not significant. This study suggests that propofol has no greater proconvulsive effect than thiopental, a drug commonly used in managing status epilepticus.