A universal genotyping-microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions
A universal genotyping-microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions
复制标题
通过将通用荧光探针与从多重侵入反应中切下的 SNP 编码瓣连接而构建的通用基因分型微阵列
DOI：
10.1039/c7cc06649j
复制
发表时间：
2017-12-14
影响因子：
4.9
通讯作者：
Zou, Bingjie
中科院分区：
文献类型：
--
作者：
Chen, Zhiyao;Miao, Liyan;Zou, Bingjie
为了实现对任何SNP通用的微阵列，我们提出了一种新的方法来构建基因分型微阵列，方法是将通用荧光探针与从玻片表面的侵袭反应中切割出来的SNP编码的片断连接起来。我们提出的微阵列在建立与个性化药物相关的多个SNPs基因分型的新实验中节省了人力和成本。
To achieve a microarray universal to any SNP, we proposed a new way to construct a genotyping-microarray by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from invasive reactions on a slide surface. Our proposed microarray is labor-saving and cost-saving in setting up a new experiment for genotyping multiple SNPs, which is related to personalized medicine.