Galanin and cognition.
Galanin and cognition.
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DOI：
10.1177/1534582305274711
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发表时间：
2004-12-01
期刊：
影响因子：
--
通讯作者：
Robinson, John K
中科院分区：
文献类型：
--
作者：
Robinson, John K
自1983年发现神经肽甘丙肽以来，积累的信息表明它具有广泛的功能，包括疼痛感觉，应激反应，食欲调节以及学习和记忆。本文综述了甘丙肽在认知过程中的具体功能的证据。文献中的一致性和空白是围绕方法论和理论的基本问题组织的。这篇综述表明，虽然在几种测量学习和记忆的方法中观察到的甘丙肽的行为效应中，神经元的作用是显而易见的，但这些发现的概括性受到了对混淆和有限范围的测试条件的关注的影响。此外，据透露，许多非认知行为结构，评估甘丙肽在认知中的潜在作用相关的尚未得到彻底检查。该评论的结论是，未来的理论和实验工作如何克服这些问题，并自信地定义甘丙肽与特定认知结构的关联的性质。
Since the neuropeptide galanin's discovery in 1983, information has accumulated that implicates it in a wide range of functions, including pain sensation, stress responses, appetite regulation, and learning and memory. This article reviews the evidence for specific functions of galanin in cognitive processes. Consistencies as well as gaps in the literature are organized around basic questions of methodology and theory. This review shows that although regularities are evident in the observed behavioral effects of galanin across several methods for measuring learning and memory, generalization from these findings is tempered with concerns about confounds and a restricted range of testing conditions. Furthermore, it is revealed that many noncognitive behavioral constructs that are relevant for assessing potential roles for galanin in cognition have not been thoroughly examined. The review concludes by laying out how future theory and experimental work can overcome these concerns and confidently define the nature of the association of galanin with particular cognitive constructs.