Differential Effect of Two Types of Anesthesia on Sound-Driven Oscillations in the Rat Primary Auditory Cortex
Differential Effect of Two Types of Anesthesia on Sound-Driven Oscillations in the Rat Primary Auditory Cortex
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DOI：
10.1007/978-3-319-46672-9_41
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Hisayuki Osanai;T. Tateno
中科院分区：
文献类型：
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作者：
Hisayuki Osanai;T. Tateno
神经振荡被认为反映了神经群体的活动，因此与大脑功能密切相关。然而，不同麻醉剂对这种振荡产生独特影响的程度尚不清楚。最近开发了三种麻醉剂（美托咪定、咪达唑仑和布托啡诺）的混合物作为氯胺酮的替代品，氯胺酮具有潜在的成瘾作用。然而，关于这种麻醉剂组合对神经振荡的影响知之甚少。在这项研究中，我们使用多通道电生理记录和黄素蛋白内源性成像比较氯胺酮与美托咪定，咪达唑仑和布托啡诺混合物给药后初级听觉皮层神经元的声音驱动振荡。我们观察到这两种麻醉剂在高γ活动（超过120 Hz）方面的差异，与皮质层无关，但在包括低频成分（<120 Hz）在内的活动方面没有发现差异。我们的研究结果提供了关于特定麻醉剂如何影响声音驱动的神经振荡的新信息。
Neural oscillations are considered to reflect the activity of neural populations, and are thus closely associated with brain function. However, the extent to which different anesthetic agents exert unique effects on such oscillations is unclear. A mixture of three anesthetics (medetomidine, midazolam, and butorphanol) was recently developed as an alternative to ketamine, which has potential addictive effects. Yet, little is known about the effects of this combination of anesthetics on neural oscillations. In this study, we used multi-channel electrophysiological recording and flavoprotein endogenous imaging to compare sound-driven oscillations in primary auditory cortical neurons after administration of ketamine vs. a medetomidine, midazolam, and butorphanol mixture. We observed differences in high gamma activities (over 120 Hz) between these two anesthetics, independent of cortical layers, but found no differences in activities including lower frequency components (<120 Hz). Our results provide new information about how specific anesthetics influence sound-driven neural oscillations.