Regulation of adrenocortical function by cytokines--relevance for immune-endocrine interaction.
Regulation of adrenocortical function by cytokines--relevance for immune-endocrine interaction.
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细胞因子调节肾上腺皮质功能——与免疫内分泌相互作用的相关性。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
S. Bornstein
中科院分区：
文献类型：
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作者：
C. Marx;M. Ehrhart‐Bornstein;W. Scherbaum;S. Bornstein
下丘脑-垂体-肾上腺轴（HPA）对免疫功能调节的重要性在过去已得到极大的重视（1 - 3）。由于给定刺激而激活HPA轴导致调节免疫应答的应激应答。免疫系统和HPA轴之间的相互作用可以通过一个回路来表征，该回路包括I）HPA轴的激活和应激反应的启动，其在术语上具有免疫调节特性; II）源自免疫系统的反馈机制，其调节HPA轴。目前关于这些调节回路的概念主要倾向于细胞因子作为免疫-内分泌调节回路的介质的作用，其已被证明在HPA轴的所有水平上干扰内分泌系统。在过去的几年中，已经证明肾上腺本身作为HPA轴的主要效应器官，是许多细胞因子合成和作用的主要场所。这篇综述总结了目前的知识生产，行动，以及功能的影响，细胞因子的行动在肾上腺发育，健康和疾病。
The importance of the hypothalamic-pituitary-adrenalaxis (HPA) for the regulation of immunological functions has been greatly appreciated in the past (1-3). Activation of the HPA axis due to a given stimulus leads to a stress response which modulates the immune response. The interactions between the immune system and HPA-axis may be characterized by a circuit which includes I) activation of the HPA-axis and initiation of the stress response which, in term, has immune-modulating properties; II) a feedback mechanism derived from the immune system which regulates the HPA-axis. Current concepts on these regulatory circuits mainly favor the action of cytokines as mediators of the immune-endocrine regulation circuits which have been shown to interfere with the endocrine system on all levels of the HPA-axis. Over the past few years, it has become evident that the adrenal gland, itself, as the main effector organ of the HPA-axis, is a major site for both synthesis and action of numerous cytokines. This review summarizes current knowledge on production, action, as well as functional implications of cytokine action within the adrenal gland during development, health and disease.