ELECTRICALLY EVOKED WHOLE-NERVE ACTION-POTENTIALS - PARAMETRIC DATA FROM THE CAT
ELECTRICALLY EVOKED WHOLE-NERVE ACTION-POTENTIALS - PARAMETRIC DATA FROM THE CAT
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DOI：
10.1121/1.400117
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发表时间：
1990-11-01
影响因子：
2.4
通讯作者：
ABBAS, PJ
中科院分区：
文献类型：
--
作者：
BROWN, CJ;ABBAS, PJ
在一篇配套论文中[Brown等人，J. Acoust.美国社会88，1385-1391（1990）]，报道了一种用于记录人类耳蜗植入物使用者的电诱发的全神经动作电位的方法。记录反应的过程需要两个双相电流脉冲，一个“掩蔽器”和一个“探针”，以足以驱动听觉神经进入不应状态的速率和水平呈现。本研究旨在评估该记录技术对刺激参数变化的敏感性。本文的实验结果表明：（1）猫的EAP是三相的，在潜伏期出现两个约为0.26和0.82ms的负峰，（2）当电流水平等于或大于探针刺激电流水平时，EAP振幅与掩蔽刺激的水平无关;以及（3）EAP从不应状态恢复的时间过程在探测和掩蔽电流水平的范围内是稳定的。
In a companion paper [Brown et al., J. Acoust. Soc. Am. 88, 1385-1391 (1990)], a method for recording the electrically evoked whole-nerve action potential in human cochlear implant users was reported. The procedure for recording the response requires that two biphasic current pulses, a "masker" and a "probe", be presented at a rate and level sufficient to drive the auditory nerve into a refractory state. The present study was designed to assess the sensitivity of that recording technique to variations in stimulation parameters. The experiments described in this paper demonstrate that: (1) the EAP as recorded in the cat is triphasic and is defined by two negative peaks occurring at latencies of approximately 0.26 and 0.82 ms; (2) EAP amplitude is independent of the level of the masker stimulus for current levels equal to or greater than the current level of the probe stimulus; and (3) the time course of recovery of the EAP from the refractory state is stable over a range of both probe and masker current levels.