Isoprenylated naphthoquinone dimers firmianones A, B, and C from Firmiana platanifolia
Isoprenylated naphthoquinone dimers firmianones A, B, and C from Firmiana platanifolia
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DOI：
10.1021/np050019l
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发表时间：
2005-08-01
影响因子：
5.1
通讯作者：
Hu, LH
中科院分区：
文献类型：
--
作者：
Bai, HY;Li, S;Hu, LH
分离得到3个新化合物，命名为Firmianone A、B和C(1-3)，并分离得到13个已知化合物。通过HRESIMS、H-1-H-1 COSY、HMQC、HMBC和NOESY的解析，确定了它们的结构。通过CD激子耦合实验确定了具有稀有六环骨架的苹果酮A和B的绝对构型。马鞭草酮A和B对P388癌细胞具有中等的细胞毒作用。
Three new compounds designated as firmianones A, B, and C (1-3), along with 13 known compounds, were isolated from the roots of Firmiana platanifolia. Their structures were elucidated by interpretation of HRESIMS, H-1-H-1 COSY, HMQC, HMBC, and NOESY. The absolute configurations of firmianones A and B with a rare hexacyclic skeleton were determined by CD exciton-coupling experiments. Firmianones A and B exhibited moderate cytotoxicity to the P388 cancer cell line.