Effects of Chronic Anemia on the Coronary and Coronary Collateral Vasculature in Dogs
Effects of Chronic Anemia on the Coronary and Coronary Collateral Vasculature in Dogs
复制标题
慢性贫血对犬冠状动脉和冠状动脉侧支血管的影响
作者：
K. Scheel;D. Brody;L. Ingram;F. Keller
我们将一组正常狗（血细胞比容 40）的冠状动脉阻力和侧支（逆行）流量与一组患有严重慢性贫血的狗（血细胞比容 17）的值进行了比较。我们使用了离体心脏制剂，其中血管被双嘧达莫最大程度地扩张。所有数据均以血细胞比容 40 进行比较。结果显示，贫血时冠状动脉阻力显着下降；对照犬的前降支、回旋支和右冠状动脉的平均阻力（±se）分别为1.04±0.09、0.74±0.01和2.63±0.17mmHg/[（ml/min）/100g]，而对照组犬的平均阻力（±se）分别为0.6±0.04、0.41±0.05和1.17±0.15。贫血的狗。贫血时平均冠状动脉侧支流量增加，但无法显示统计学显着性。我们的结论是，血管分布增加是响应缺氧刺激的长期调节机制。
We compared coronary resistances and collateral (retrograde) flows for a group of normal dogs (hematocrit 40) to values for a group of dogs with severe chronic anemia (hematocrit 17). We used an isolated heart preparation in which the vessels were maximally dilated by dipyridamole. All data were compared for a hematocrit of 40. The results showed a significant decrease in coronary resistances with anemia; average resistances (±se) of the anterior descending, circumflex, and right coronary arteries of the control dogs were 1.04 ± 0.09,0.74 ± 0.01, and 2.63 ± 0.17 mm Hg/ [(ml/min)/100 g], respectively, and 0.6 ± 0.04,0.41 ± 0.05, and 1.17 ± 0.15 for the anemic dogs. Average coronary collateral flows increased in anemia but statistical significance could not be shown. We conclude that increased vascularity is a long-term regulatory mechanism in response to a hypoxic stimulus.