PROLACTIN INDUCTION OF INTERLEUKIN-2 RECEPTORS ON RAT SPLENIC LYMPHOCYTES
PROLACTIN INDUCTION OF INTERLEUKIN-2 RECEPTORS ON RAT SPLENIC LYMPHOCYTES
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DOI：
10.1210/endo-126-1-88
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发表时间：
1990-01-01
期刊：
影响因子：
4.8
通讯作者：
HYMER, WC
中科院分区：
文献类型：
--
作者：
MUKHERJEE, P;MASTRO, AM;HYMER, WC
PRL参与免疫系统调节的理由很充分。然而，PRL实施这一规定的机制尚未确定。本文研究了催乳素(PRL)对去卵巢(OVX)大鼠脾细胞的体外作用，发现PRL可诱导白细胞介素2(IL-2)细胞表面受体的形成。但PRL不能诱导IL-2的分泌。这种反应依赖于PRL的浓度，也依赖于脾细胞供者的雌激素状态；因此，去卵巢大鼠或发情间期大鼠的脾细胞对PRL有反应，而雌激素处理的去卵巢大鼠或发情大鼠的脾细胞对PRL没有反应。我们认为，在体内暴露PRL，在一定的生理条件下，可能启动一个脾细胞池来表达IL-2细胞表面受体，使这些细胞对局部浓度的变化有反应。
A case for the involvement of PRL in the regulation of the immune system is strong. However, no mechanism by which PRL exerts this regulation has yet been identified. We studied the in vitro effects of PRL on splenocytes from ovariectomized (OVX) rats and discovered that PRL induced the formation of interleukin-2 (IL-2) cell surface receptors. However, PRL did not induce IL-2 secretion. This response, which was dependent on the concentration of PRL, also depended upon the estrogen status of the splenocyte donor; thus, splenocytes from OVX rats or rats in diestrus responded to PRL, whereas those from estrogen-treated OVX rats or rats in estrus did not. We propose that in vivo exposure of PRL, under certain physiological conditions, may prime a pool of splenocytes to express IL-2 cell surface receptors, allowing these cells to be responsive to variation in local concentration.