A shift in the third-codon-position nucleotide frequency in alcohol dehydrogenase genes in the genus Drosophila.
A shift in the third-codon-position nucleotide frequency in alcohol dehydrogenase genes in the genus Drosophila.
复制标题
果蝇属乙醇脱氢酶基因第三个密码子位置核苷酸频率的变化。
DOI：
10.1093/oxfordjournals.molbev.a040571
复制
发表时间：
1989
影响因子：
10.7
通讯作者：
Sullivan,DT
中科院分区：
文献类型：
--
作者：
Starmer,WT;Sullivan,DT
物种内和物种间蛋白质的任何一种氨基酸的替代同义密码子（密码子使用）的相对出现频率的检查表明，密码子使用模式是基因组表达和单个基因表达的重要组成部分。这种概括意味着密码子使用的功能作用，因此不同谱系之间的同义替换率可能不同。这可能会影响模型构建估计进化速率，以及有关系统发育重建的推论。穆希鲁和戈蒂埃
Examination of the relative frequency of occurrence of alternative synonymous codons for any one amino acid (codon usage) for proteins within and among species suggests that codon usage pattern is a significant component of both genomic expression and expression of individual genes. This generalization implies a functional role of codon usage and that synonymous substitution rates may differ between lineages as a consequence. This could effect models constructed to estimate evolutionary rates, as well as inferences regarding phylogenetic reconstruction. Mouchiroud and Gautier