The density of [I-125]-transferrin binding sites on perikarya of melanized neurons of the substantia nigra is decreased in Parkinson's disease
The density of [I-125]-transferrin binding sites on perikarya of melanized neurons of the substantia nigra is decreased in Parkinson's disease
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DOI：
10.1016/s0006-8993(96)01412-6
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发表时间：
1997-02-21
期刊：
影响因子：
2.9
通讯作者：
Hirsch, EC
中科院分区：
文献类型：
--
作者：
Faucheux, BA;Hauw, JJ;Hirsch, EC
应用体外培养脑切片定量放射自显影技术，在细胞水平上研究了帕金森病患者和对照组中脑黑化神经元上[(125)]-二铁-转铁蛋白结合部位的密度。在帕金森病患者中，平均密度降低，黑质腹侧层的差异在统计学上具有显著意义，这是该病中受神经元死亡影响最大的区域。在积累铁的神经元群体中，核膜上转铁蛋白受体的数量没有增加，这可能反映了真核细胞中铁含量决定的转铁蛋白受体数量的转录后基因调控。
The density of [(125)]-diferric-transferrin binding sites was investigated at the cellular level on melanized neurons located in the mesencephalon of patients with Parkinson's disease and control subjects, using quantitative autoradiography of in vitro incubated brain sections. In parkinsonian patients mean densities were reduced, the difference being statistically significant for the ventral tier of the substantia nigra, which is the subregion most affected by neuronal death in the disease. The absence of increase in the number of transferrin receptors on the perikarya within a population of neurons accumulating iron probably reflects the post-transcriptional gene regulation of the number of transferrin receptors that depends upon iron content in eukaryote cells.