Cardiorespiratory fitness attenuates metabolic risk independent of abdominal subcutaneous and visceral fat in men
Cardiorespiratory fitness attenuates metabolic risk independent of abdominal subcutaneous and visceral fat in men
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DOI：
10.2337/diacare.28.4.895
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发表时间：
2005-04-01
期刊：
影响因子：
16.2
通讯作者：
Ross, R
中科院分区：
文献类型：
--
作者：
Lee, S;Kuk, JL;Ross, R
目的 - 中度至高水平的心肺健康 (CRF) 与较低的代谢综合征和全因死亡率风险相关。目前尚不清楚 CRF 是否会减轻给定水平的腹部内脏脂肪、皮下脂肪和/或腰围的健康风险。 研究设计和方法 - 研究样本包括 297 名表面健康的男性，他们拥有腹部计算机断层扫描或磁共振成像扫描、代谢数据和最大跑步机运动测试结果。根据年龄和运动测试结果，男性被分为低 CRF（20%，n = 56）、中 CRF（40%，n = 94）和高 CRF（40%，n = 147）组。所有分析均根据年龄进行调整。 结果 - 对于给定水平的腰围、内脏脂肪或皮下脂肪，高 CRF 组的甘油三酯水平较低 (P < 0.05)，HDL 胆固醇水平高于低或中等 CRF 组。血压存在显着的组间交互作用（P < 0.01），表明与高 CRF 组相比，低 CRF 组的男性内脏脂肪或腰围每增加单位血压的升高幅度更大。调整年龄、内脏脂肪和皮下脂肪后，与高 CRF 组相比，低 CRF 组和中 CRF 组患代谢综合征的相对风险分别高 1.8 (95% Cl 1.0-3.1) 和 1.6 (0.9-2.7) 倍（趋势 P = 0.06）。 结论 - 高水平 CRF 与给定水平的健康风险大幅降低相关。内脏和皮下脂肪。
OBJECTIVE - Moderate to high levels of cardiorespiratory fitness (CRF) are associated with a lower risk of the metabolic syndrome and all-cause mortality. Unknown is whether CRF attenuates health risk for a given level of abdominal visceral fat, subcutaneous fat, and/or waist circumference.RESEARCH DESIGN AND METHODS - The sample studied comprised 297 apparently healthy men with available computed tomography or magnetic resonance imaging scans of the abdomen, metabolic data, and maximal treadmill exercise test results. Men were categorized into low-CRF (20%, n = 56), moderate-CRF (40%, n = 94), and high-CRF (40%, n = 147) groups based on age and exercise test results. All analyses were adjusted for age.RESULTS - For a given level of waist circumference, visceral fat, or subcutaneous fat, the high-CRF group had lower triglyceride levels (P < 0.05) and higher HDL cholesterol levels than the low- or moderate-CRF groups. There was a significant group interaction (P < 0.01.) for blood pressure, indicating that the increase in blood pressure per unit increase in visceral fat Or waist circumference was greater in men in the low-CRF group compared with the high-CRF group. The relative risks of having the metabolic syndrome were 1.8 (95% Cl 1.0-3.1) and 1.6 (0.9-2.7) times higher in the low- and moderate-CRF groups, respectively, compared With the high-CRF group after adjusting for age, visceral fat, and subcutaneous Fat (P for trend = 0.06).CONCLUSIONS - High levels of CRF are associated With a substantial reduction in health risk for a given level of visceral and subcutaneous fat.