Gynecologic cancer incidence and mortality among American Indian/Alaska Native women in the Pacific Northwest, 1996-2016
Gynecologic cancer incidence and mortality among American Indian/Alaska Native women in the Pacific Northwest, 1996-2016
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DOI：
10.1016/j.ygyno.2020.03.033
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发表时间：
2020-06-01
影响因子：
4.7
通讯作者：
Becker, Thomas
中科院分区：
文献类型：
--
作者：
Bruegl, Amanda S.;Joshi, Sujata;Becker, Thomas
目标。比较太平洋西北地区美洲印第安人/阿拉斯加原住民 (AI/AN) 妇女与非西班牙裔白人 (NHW) 人群的妇科癌症发病率和死亡率。方法。根据从华盛顿州、俄勒冈州和爱达荷州获得的基于人口的州癌症登记和死亡证明数据计算了年龄调整后的癌症发病率（1996-2016）和死亡率（2006-2016），并纠正了 AI/AN 错误分类。计算发病率和死亡率比 (RR)，以比较患有妇科癌症的 AI/AN 和 NHW 妇女。结果。在所有妇科癌症部位，与 NHW 女性相比，AI/AN 女性被诊断的年龄更小。与 NHW 女性相比，AI/AN 女性的宫颈癌发病率更高，RR 为 1.53（95% CI：1.34，1.75）。对于所有年龄组，AI/AN 女性的宫颈癌发病率较高，50-64 岁年龄组的差异最大，RR 为 1.76（95% CI：1.36，2.30）。 AI/AN 女性的宫颈癌死亡率更高，所有年龄段的 RR 为 1.79（95% CI：1.30，2.46）； 50-64岁年龄组的差异最大（RR：2.88，95％CI：1.89，4.38）。对于子宫癌，AI/AN 女性的发病率与 NHW 女性相似，但死亡率更高（RR：1.35，95% CI：1.03-1.75）。各组之间卵巢癌的发病率和死亡率相似。结论。我们对 PNW 地区 AI/AN 妇女的妇科癌症分析发现，与 NHW 妇女相比，宫颈癌发病率和死亡率存在显着差异。尽管预防策略取得了进步，但这些差异仍然存在。由爱思唯尔公司出版
Objectives. Compare the incidence and mortality of gynecologic cancers among American Indian/Alaska Native (AI/AN) women to the Non-Hispanic White (NHW) population in the Pacific Northwest.Methods. Age-adjusted cancer incidence (1996-2016) and mortality (2006-2016) rates were calculated from population-based state cancer registry and death certificate data obtained from Washington, Oregon, and Idaho, and corrected for AI/AN misclassification. Incidence and mortality rate ratios (RR) were calculated to compare AI/AN and NHW women with gynecologic cancers.Results. Across all gynecologic cancer sites, AI/AN women were diagnosed at a younger age compared to NHW women. AI/AN women had a higher incidence of cervical cancer compared to NHW women with a RR of 1.53 (95% CI: 1.34, 1.75). For all age groups, AI/AN women had a higher incidence of cervical cancer and the disparity was greatest in the 50-64 age group with a RR of 1.76 (95% CI: 1.36, 2.30). Cervical cancer mortality was greater among AI/AN women, with an all-ages RR of 1.79 (95% CI: 1.30, 2.46); the disparity was greatest in the 50-64 age group (RR: 2.88, 95% CI: 1.89, 4.38). For uterine cancer, AI/AN women had similar incidence rates as NHW women but higher mortality rates (RR: 1.35, 95% CI: 1.03-1.75). Incidence and mortality for ovarian cancer were similar between groups.Conclusion. Our analysis of gynecologic cancers among AI/AN in the PNW found significant disparities relative to NHW women in cervical cancer incidence and mortality. These disparities persist despite advances in prevention strategies. Published by Elsevier Inc.