Does warfarin therapy influence the risk of bladder cancer?
Does warfarin therapy influence the risk of bladder cancer?
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DOI：
10.1160/th03-08-0553
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发表时间：
2004-04-01
影响因子：
6.7
通讯作者：
Mason, TJ
中科院分区：
文献类型：
--
作者：
Blumentals, WA;Foulis, PR;Mason, TJ
人们对研究某些药物的生物效应及其降低各种癌症风险的潜力越来越感兴趣。一项研究报告称，在一项针对接受华法令治疗静脉血栓栓塞的患者的试验中，泌尿生殖系统癌症的发病率有所下降，但这项泌尿生殖系统癌症研究的局限性是在华法令治疗后发生的膀胱癌病例数量很少。本研究的目的是测量华法林使用与膀胱癌之间的关系。在詹姆斯A。位于佛罗里达坦帕的海利退伍军人管理局（VA）医院，使用计算机化病理记录和住院及门诊诊断相结合。从VA计算机化管理数据库中随机选择对照，并纳入1293例对照进行分析。在调整年龄、性别和吸烟后，进行非条件logistic回归分析以评估膀胱癌的风险。在华法林使用者中，虽然风险增加了27%，但与非使用者相比没有显著差异（OR = 1.27，95%CI = 0.85，1.89）。抗凝剂使用与膀胱癌风险之间未观察到持续时间-反应关系。结果表明，华法林不能预防膀胱癌，至少在男性吸烟者中是膀胱癌的最高风险人群。
There has been growing interest in studying the biological effects of certain drugs and their potential to reduce the risk of various cancers. One study reported a decrease in the incidence of urogenital cancers in a trial with patients who received warfarin for treatment of venous thromboembolism, but a limitation to this study of urogenital cancers was the very small number of bladder cancer cases that developed following warfarin therapy. The objective of the present study is to measure the association between warfarin use and bladder cancer. A total of 330 cases with bladder cancer were identified at the James A. Haley Veterans' Administration (VA) Hospital in Tampa, Florida, using a combination of computerized pathology records and inpatient and outpatient diagnoses. Controls were randomly selected from the VA computerized administrative database and 1293 controls were included for analysis. Unconditional logistic regression analysis was performed to assess the risk of bladder cancer after adjusting for age, gender, and cigarette smoking. Among warfarin users, although there was a 27% elevation in risk, it did not differ significantly from nonusers (OR = 1.27, 95% CI = 0.85, 1.89). No duration-response relationship was observed between anticoagulant use and risk of bladder cancer. The results suggest that warfarin does not protect against bladder cancer, at least in male smokers, the highest risk population for bladder cancer.