IgE Antibodies against Cancer: Efficacy and Safety.
IgE Antibodies against Cancer: Efficacy and Safety.
复制标题
抗癌的IgE抗体：功效和安全性。
DOI：
10.3390/antib9040055
复制
发表时间：
2020-10-16
期刊：
影响因子：
--
通讯作者：
Bax HJ
中科院分区：
文献类型：
--
作者：
Chauhan J;McCraw AJ;Nakamura M;Osborn G;Sow HS;Cox VF;Stavraka C;Josephs DH;Spicer JF;Karagiannis SN;Bax HJ
免疫球蛋白E（IgE）抗体在过敏性疾病中的作用以及对抗寄生虫免疫应答的贡献是众所周知的。介导强大效应子功能的这种抗体类别的特性可以被重定向用于实体瘤的治疗。这导致了一类新的治疗性抗体的出现，以补充批准的肿瘤靶向抗体的设备，迄今为止，这些抗体都是IgG类。IgE给药后I型超敏反应的感知风险使得在开发这些治疗药物时需要特别考虑。在这里，我们汇集了IgE抗体的特性关键的假设相比，IgG的上级抗肿瘤活性，在体外和体内的疗效和作用机制的观察，并专注于这类新的治疗药物的安全性考虑。这些包括潜在超敏反应的体外研究、适当体内动物模型的选择和观察以及IgE高度糖基化的可能影响。我们还讨论了体外预测和监测临床工具的使用，以及在候选抗癌IgE治疗剂的首次人体临床试验中采用的风险缓解步骤和初步结果。
Immunoglobulin E (IgE) antibodies are well known for their role in allergic diseases and for contributions to antiparasitic immune responses. Properties of this antibody class that mediate powerful effector functions may be redirected for the treatment of solid tumours. This has led to the rise of a new class of therapeutic antibodies to complement the armamentarium of approved tumour targeting antibodies, which to date are all IgG class. The perceived risk of type I hypersensitivity reactions following administration of IgE has necessitated particular consideration in the development of these therapeutic agents. Here, we bring together the properties of IgE antibodies pivotal to the hypothesis for superior antitumour activity compared to IgG, observations of in vitro and in vivo efficacy and mechanisms of action, and a focus on the safety considerations for this novel class of therapeutic agent. These include in vitro studies of potential hypersensitivity, selection of and observations from appropriate in vivo animal models and possible implications of the high degree of glycosylation of IgE. We also discuss the use of ex vivo predictive and monitoring clinical tools, as well as the risk mitigation steps employed in, and the preliminary outcomes from, the first-in-human clinical trial of a candidate anticancer IgE therapeutic.
登录
查看更多内容
影响因子：
30.5
作者：
Crawford G;Hayes MD;Seoane RC;Ward S;Dalessandri T;Lai C;Healy E;Kipling D;Proby C;Moyes C;Green K;Best K;Haniffa M;Botto M;Dunn-Walters D;Strid J
通讯作者：
Strid J
影响因子：
4.4
作者：
Dombrowicz, D;Quatannens, B;Capron, M
通讯作者：
Capron, M
DOI：
10.1073/pnas.86.19.7566
发表时间：
1989-10-01
影响因子：
11.1
作者：
BETTLER, B;HOFSTETTER, H;CONRAD, DH
通讯作者：
CONRAD, DH
影响因子：
3.8
作者：
Daniels-Wells, Tracy R.;Helguera, Gustavo;Penichet, Manuel L.
通讯作者：
Penichet, Manuel L.
影响因子：
14.2
作者：
Crescioli, Silvia;Chiaruttini, Giulia;Karagiannis, Sophia N.
通讯作者：
Karagiannis, Sophia N.